Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four group...
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-09-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2021-0077 |
| _version_ | 1818025271267164160 |
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| author | Zhang Jing Yao Ming-yan Zhang Guo-rui Chen Xian-ru Liu Qi Guo Yifang Jia Xin-wei |
| author_facet | Zhang Jing Yao Ming-yan Zhang Guo-rui Chen Xian-ru Liu Qi Guo Yifang Jia Xin-wei |
| author_sort | Zhang Jing |
| collection | DOAJ |
| description | This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four groups (nA = 9, nB = 7, nC = 7, and nD = 7 rabbits): rabbits in group-A (control group) were fed a high-fat diet, group-B rabbits were fed a high-fat diet plus 2.5 mg/kg/day S-amlodipine, group-C rabbits were fed a high-fat diet plus 2.5 mg/kg/day R-amlodipine, and group-D rabbits were fed a high-fat diet plus 5 mg/kg/day racemic amlodipine. Different enantiomers of amlodipine did not influence lipid profiles and serum level of eNOS in the rabbit atherosclerosis model but decreased ET-1 expression to some extent. The serum NO and iNOS levels in the drug intervention groups were significantly reduced. No significant differences in the rabbits’ body weights were observed. At the 4th and 8th weeks, the serum lipid profiles significantly increased in high cholesterol diet groups. The serum ET-1 level was significantly increased in each group of rabbits at the 8th week. Both S-amlodipine and R-amlodipine may protect the endothelium by reducing the serum ET-1 level, downregulating iNOS expression. |
| first_indexed | 2024-12-10T04:13:27Z |
| format | Article |
| id | doaj.art-c463b738ef0b4e12841ce9b8109123f6 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-12-10T04:13:27Z |
| publishDate | 2021-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-c463b738ef0b4e12841ce9b8109123f62022-12-22T02:02:40ZengDe GruyterOpen Life Sciences2391-54122021-09-0116189990810.1515/biol-2021-0077Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbitsZhang Jing0Yao Ming-yan1Zhang Guo-rui2Chen Xian-ru3Liu Qi4Guo Yifang5Jia Xin-wei6Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, ChinaDepartment of Endocrinology, Baoding No. 1 Central Hospital, Baoding, Hebei, 071000, ChinaDepartment of Cardiology, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, 050000, ChinaDepartment of Cardiology, Affiliated Hospital of Hebei Engineering University, Handan, Hebei, 056000, ChinaDepartment of Cardiology, Shijiazhuang Traditional Chinese Medicine Hospital, Shijiazhuang, Hebei, 050000, ChinaCardiology Division in Geriatric Institute, Hebei Provincial People’s Hospital, Shijiazhuang, Hebei, 050000, ChinaDepartment of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, ChinaThis research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four groups (nA = 9, nB = 7, nC = 7, and nD = 7 rabbits): rabbits in group-A (control group) were fed a high-fat diet, group-B rabbits were fed a high-fat diet plus 2.5 mg/kg/day S-amlodipine, group-C rabbits were fed a high-fat diet plus 2.5 mg/kg/day R-amlodipine, and group-D rabbits were fed a high-fat diet plus 5 mg/kg/day racemic amlodipine. Different enantiomers of amlodipine did not influence lipid profiles and serum level of eNOS in the rabbit atherosclerosis model but decreased ET-1 expression to some extent. The serum NO and iNOS levels in the drug intervention groups were significantly reduced. No significant differences in the rabbits’ body weights were observed. At the 4th and 8th weeks, the serum lipid profiles significantly increased in high cholesterol diet groups. The serum ET-1 level was significantly increased in each group of rabbits at the 8th week. Both S-amlodipine and R-amlodipine may protect the endothelium by reducing the serum ET-1 level, downregulating iNOS expression.https://doi.org/10.1515/biol-2021-0077atherosclerosisr-amlodipines-amlodipinevecs |
| spellingShingle | Zhang Jing Yao Ming-yan Zhang Guo-rui Chen Xian-ru Liu Qi Guo Yifang Jia Xin-wei Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits Open Life Sciences atherosclerosis r-amlodipine s-amlodipine vecs |
| title | Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits |
| title_full | Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits |
| title_fullStr | Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits |
| title_full_unstemmed | Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits |
| title_short | Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits |
| title_sort | effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits |
| topic | atherosclerosis r-amlodipine s-amlodipine vecs |
| url | https://doi.org/10.1515/biol-2021-0077 |
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