Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart
The effect of human fetal heart geometry and anisotropy on anatomy induced drift and self-termination of cardiac re-entry is studied here in MRI based 2D slice and 3D whole heart computer simulations. Isotropic and anisotropic models of 20 weeks of gestational age human fetal heart obtained from 100...
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| Format: | Article |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Physics |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphy.2018.00015/full |
| _version_ | 1819095342589673472 |
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| author | Irina V. Biktasheva Irina V. Biktasheva Richard A. Anderson Arun V. Holden Eleftheria Pervolaraki Fen Cai Wen |
| author_facet | Irina V. Biktasheva Irina V. Biktasheva Richard A. Anderson Arun V. Holden Eleftheria Pervolaraki Fen Cai Wen |
| author_sort | Irina V. Biktasheva |
| collection | DOAJ |
| description | The effect of human fetal heart geometry and anisotropy on anatomy induced drift and self-termination of cardiac re-entry is studied here in MRI based 2D slice and 3D whole heart computer simulations. Isotropic and anisotropic models of 20 weeks of gestational age human fetal heart obtained from 100 μm voxel diffusion tensor MRI data sets were used in the computer simulations. The fiber orientation angles of the heart were obtained from the orientation of the DT-MRI primary eigenvectors. In a spatially homogeneous electrophysiological monodomain model with the DT-MRI based heart geometries, cardiac re-entry was initiated at a prescribed location in a 2D slice, and in the 3D whole heart anatomy models. Excitation was described by simplified FitzHugh-Nagumo kinetics. In a slice of the heart, with propagation velocity twice as fast along the fibers than across the fibers, DT-MRI based fiber anisotropy changes the re-entry dynamics from pinned to an anatomical re-entry. In the 3D whole heart models, the fiber anisotropy changes cardiac re-entry dynamics from a persistent re-entry to the re-entry self-termination. The self-termination time depends on the re-entry's initial position. In all the simulations with the DT-MRI based cardiac geometry, the anisotropy of the myocardial tissue shortens the time to re-entry self-termination several folds. The numerical simulations depend on the validity of the DT-MRI data set used. The ventricular wall showed the characteristic transmural rotation of the helix angle of the developed mammalian heart, while the fiber orientation in the atria was irregular. |
| first_indexed | 2024-12-21T23:41:47Z |
| format | Article |
| id | doaj.art-c465863c4b394021b790bf94efcadf8c |
| institution | Directory Open Access Journal |
| issn | 2296-424X |
| language | English |
| last_indexed | 2024-12-21T23:41:47Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physics |
| spelling | doaj.art-c465863c4b394021b790bf94efcadf8c2022-12-21T18:46:12ZengFrontiers Media S.A.Frontiers in Physics2296-424X2018-02-01610.3389/fphy.2018.00015327090Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal HeartIrina V. Biktasheva0Irina V. Biktasheva1Richard A. Anderson2Arun V. Holden3Eleftheria Pervolaraki4Fen Cai Wen5Department of Computer Science, University of Liverpool, Liverpool, United KingdomCEMPS, University of Exeter, Exeter, United KingdomMRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United KingdomSchool of Biomedical Sciences, University of Leeds, Leeds, United KingdomSchool of Biomedical Sciences, University of Leeds, Leeds, United KingdomDepartment of Computer Science, University of Liverpool, Liverpool, United KingdomThe effect of human fetal heart geometry and anisotropy on anatomy induced drift and self-termination of cardiac re-entry is studied here in MRI based 2D slice and 3D whole heart computer simulations. Isotropic and anisotropic models of 20 weeks of gestational age human fetal heart obtained from 100 μm voxel diffusion tensor MRI data sets were used in the computer simulations. The fiber orientation angles of the heart were obtained from the orientation of the DT-MRI primary eigenvectors. In a spatially homogeneous electrophysiological monodomain model with the DT-MRI based heart geometries, cardiac re-entry was initiated at a prescribed location in a 2D slice, and in the 3D whole heart anatomy models. Excitation was described by simplified FitzHugh-Nagumo kinetics. In a slice of the heart, with propagation velocity twice as fast along the fibers than across the fibers, DT-MRI based fiber anisotropy changes the re-entry dynamics from pinned to an anatomical re-entry. In the 3D whole heart models, the fiber anisotropy changes cardiac re-entry dynamics from a persistent re-entry to the re-entry self-termination. The self-termination time depends on the re-entry's initial position. In all the simulations with the DT-MRI based cardiac geometry, the anisotropy of the myocardial tissue shortens the time to re-entry self-termination several folds. The numerical simulations depend on the validity of the DT-MRI data set used. The ventricular wall showed the characteristic transmural rotation of the helix angle of the developed mammalian heart, while the fiber orientation in the atria was irregular.http://journal.frontiersin.org/article/10.3389/fphy.2018.00015/fullcardiac arrhythmiasanatomically realistic modelinganisotropyanatomy induced driftFitzHugh-Nagumo model |
| spellingShingle | Irina V. Biktasheva Irina V. Biktasheva Richard A. Anderson Arun V. Holden Eleftheria Pervolaraki Fen Cai Wen Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart Frontiers in Physics cardiac arrhythmias anatomically realistic modeling anisotropy anatomy induced drift FitzHugh-Nagumo model |
| title | Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart |
| title_full | Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart |
| title_fullStr | Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart |
| title_full_unstemmed | Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart |
| title_short | Cardiac Re-entry Dynamics and Self-termination in DT-MRI Based Model of Human Fetal Heart |
| title_sort | cardiac re entry dynamics and self termination in dt mri based model of human fetal heart |
| topic | cardiac arrhythmias anatomically realistic modeling anisotropy anatomy induced drift FitzHugh-Nagumo model |
| url | http://journal.frontiersin.org/article/10.3389/fphy.2018.00015/full |
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