Clonidine for management of chronic pain: A brief review of the current evidences
Clonidine, an alpha-2 adrenergic receptor agonist, has well-established role in acute perioperative pain management. However, recently it has found increasing use in chronic pain conditions as well. In this review, we systematically searched and analyzed the clinical studies from "PubMed,"...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Saudi Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=1;spage=92;epage=96;aulast=Kumar |
| _version_ | 1819118141595189248 |
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| author | Anil Kumar Souvik Maitra Puneet Khanna Dalim Kumar Baidya |
| author_facet | Anil Kumar Souvik Maitra Puneet Khanna Dalim Kumar Baidya |
| author_sort | Anil Kumar |
| collection | DOAJ |
| description | Clonidine, an alpha-2 adrenergic receptor agonist, has well-established role in acute perioperative pain management. However, recently it has found increasing use in chronic pain conditions as well. In this review, we systematically searched and analyzed the clinical studies from "PubMed," "PubMed central" and "Scopus" database for use of clonidine in the chronic pain. Quantitative meta-analysis was not possible as clonidine has been used in various patient populations through different routes. However, qualitative analysis of nearly thirty clinical studies provides some evidence that clonidine administered through epidural, intrathecal and local/topical route may be effective in chronic pain conditions where neuropathy is a predominant component. It may also be effective where opioids are of limited use due to inadequate pain relief or adverse effects. |
| first_indexed | 2024-12-22T05:44:10Z |
| format | Article |
| id | doaj.art-c465f49699b54582a2466c5d38ad5f79 |
| institution | Directory Open Access Journal |
| issn | 1658-354X |
| language | English |
| last_indexed | 2024-12-22T05:44:10Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Anaesthesia |
| spelling | doaj.art-c465f49699b54582a2466c5d38ad5f792022-12-21T18:37:07ZengWolters Kluwer Medknow PublicationsSaudi Journal of Anaesthesia1658-354X2014-01-0181929610.4103/1658-354X.125955Clonidine for management of chronic pain: A brief review of the current evidencesAnil KumarSouvik MaitraPuneet KhannaDalim Kumar BaidyaClonidine, an alpha-2 adrenergic receptor agonist, has well-established role in acute perioperative pain management. However, recently it has found increasing use in chronic pain conditions as well. In this review, we systematically searched and analyzed the clinical studies from "PubMed," "PubMed central" and "Scopus" database for use of clonidine in the chronic pain. Quantitative meta-analysis was not possible as clonidine has been used in various patient populations through different routes. However, qualitative analysis of nearly thirty clinical studies provides some evidence that clonidine administered through epidural, intrathecal and local/topical route may be effective in chronic pain conditions where neuropathy is a predominant component. It may also be effective where opioids are of limited use due to inadequate pain relief or adverse effects.http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=1;spage=92;epage=96;aulast=KumarChronic painclonidineneuropathy |
| spellingShingle | Anil Kumar Souvik Maitra Puneet Khanna Dalim Kumar Baidya Clonidine for management of chronic pain: A brief review of the current evidences Saudi Journal of Anaesthesia Chronic pain clonidine neuropathy |
| title | Clonidine for management of chronic pain: A brief review of the current evidences |
| title_full | Clonidine for management of chronic pain: A brief review of the current evidences |
| title_fullStr | Clonidine for management of chronic pain: A brief review of the current evidences |
| title_full_unstemmed | Clonidine for management of chronic pain: A brief review of the current evidences |
| title_short | Clonidine for management of chronic pain: A brief review of the current evidences |
| title_sort | clonidine for management of chronic pain a brief review of the current evidences |
| topic | Chronic pain clonidine neuropathy |
| url | http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=1;spage=92;epage=96;aulast=Kumar |
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