Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo

Comparative Molecular Analysis of Cancer Behavior Cultured In Vitro, In Vivo, and Ex Vivo

Current pre-clinical models of cancer fail to recapitulate the cancer cell behavior in primary tumors primarily because of the lack of a deeper understanding of the effects that the microenvironment has on cancer cell phenotype. Transcriptomic profiling of 4T1 murine mammary carcinoma cells from 2D...

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Bibliographic Details
Main Authors: Nicholas R. Hum, Aimy Sebastian, Sean F. Gilmore, Wei He, Kelly A. Martin, Aubree Hinckley, Karen R. Dubbin, Monica L. Moya, Elizabeth K. Wheeler, Matthew A. Coleman, Gabriela G. Loots
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
syngeneic culture
pdx
spheroid
tumoroid
monolayer culture
rna-seq
tnbc
4t1
single-cell rna-seq
emt
Online Access:https://www.mdpi.com/2072-6694/12/3/690

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