Inflammation and cutaneous nervous system involvement in hypertrophic scarring
This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that infla...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=10;spage=1678;epage=1682;aulast=Li |
| _version_ | 1819231804449619968 |
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| author | Shao-hua Li Heng-lian Yang Hu Xiao Yi-bing Wang De-chang Wang Ran Huo |
| author_facet | Shao-hua Li Heng-lian Yang Hu Xiao Yi-bing Wang De-chang Wang Ran Huo |
| author_sort | Shao-hua Li |
| collection | DOAJ |
| description | This study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation. |
| first_indexed | 2024-12-23T11:50:47Z |
| format | Article |
| id | doaj.art-c4669d62bf8b4d39adf4bf4e044734fb |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-23T11:50:47Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-c4669d62bf8b4d39adf4bf4e044734fb2022-12-21T17:48:12ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742015-01-0110101678168210.4103/1673-5374.167769Inflammation and cutaneous nervous system involvement in hypertrophic scarringShao-hua LiHeng-lian YangHu XiaoYi-bing WangDe-chang WangRan HuoThis study aimed to use a mouse model of hypertrophic scarring by mechanical loading on the dorsum of mice to determine whether the nervous system of the skin and inflammation participates in hypertrophic scarring. Results of hematoxylin-eosin and immunohistochemical staining demonstrated that inflammation contributed to the formation of a hypertrophic scar and increased the nerve density in scar tissue.Western blot assay verified that interleukin-13 expression was increased in scar tissue. These findings suggest that inflammation and the cutaneous nervous system play a role in hypertrophic scar formation.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=10;spage=1678;epage=1682;aulast=Linerve regeneration; peripheral nerve regeneration; hypertrophic scar; interleukin-13; wound healing; nerve growth factor; neural regeneration |
| spellingShingle | Shao-hua Li Heng-lian Yang Hu Xiao Yi-bing Wang De-chang Wang Ran Huo Inflammation and cutaneous nervous system involvement in hypertrophic scarring Neural Regeneration Research nerve regeneration; peripheral nerve regeneration; hypertrophic scar; interleukin-13; wound healing; nerve growth factor; neural regeneration |
| title | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
| title_full | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
| title_fullStr | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
| title_full_unstemmed | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
| title_short | Inflammation and cutaneous nervous system involvement in hypertrophic scarring |
| title_sort | inflammation and cutaneous nervous system involvement in hypertrophic scarring |
| topic | nerve regeneration; peripheral nerve regeneration; hypertrophic scar; interleukin-13; wound healing; nerve growth factor; neural regeneration |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=10;spage=1678;epage=1682;aulast=Li |
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