Use of botulinum toxin in the management of dystonia in Parkinson’s disease
Botulinum toxin is one of the most potent neurotoxins, but when injected into an overactive muscle, it can transiently alleviate an involuntary movement, such as dystonia. The primary aim of this article is to provide a comprehensive review of the various forms of dystonia observed in patients with...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1371601/full |
| _version_ | 1797219276286853120 |
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| author | Charenya Anandan Charenya Anandan Joseph Jankovic |
| author_facet | Charenya Anandan Charenya Anandan Joseph Jankovic |
| author_sort | Charenya Anandan |
| collection | DOAJ |
| description | Botulinum toxin is one of the most potent neurotoxins, but when injected into an overactive muscle, it can transiently alleviate an involuntary movement, such as dystonia. The primary aim of this article is to provide a comprehensive review of the various forms of dystonia observed in patients with Parkinson’s disease who can benefit from a therapeutic trial of botulinum toxin. Although most of these indications are not supported by randomized controlled clinical trials and, therefore, not approved by the Food and Drug Administration, there are many open-label trials supporting a large body of empirical experience testifying to the benefits of botulinum toxin treatment in these conditions. |
| first_indexed | 2024-04-24T12:31:04Z |
| format | Article |
| id | doaj.art-c467ef352a0f4aaa868ec1431534cc07 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-24T12:31:04Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-c467ef352a0f4aaa868ec1431534cc072024-04-08T04:33:04ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-04-011810.3389/fnins.2024.13716011371601Use of botulinum toxin in the management of dystonia in Parkinson’s diseaseCharenya Anandan0Charenya Anandan1Joseph Jankovic2Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX, United StatesNeurology Care Line, Michael E. DeBakey VA Medical Center, Houston, TX, United StatesDepartment of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX, United StatesBotulinum toxin is one of the most potent neurotoxins, but when injected into an overactive muscle, it can transiently alleviate an involuntary movement, such as dystonia. The primary aim of this article is to provide a comprehensive review of the various forms of dystonia observed in patients with Parkinson’s disease who can benefit from a therapeutic trial of botulinum toxin. Although most of these indications are not supported by randomized controlled clinical trials and, therefore, not approved by the Food and Drug Administration, there are many open-label trials supporting a large body of empirical experience testifying to the benefits of botulinum toxin treatment in these conditions.https://www.frontiersin.org/articles/10.3389/fnins.2024.1371601/fulldystoniaParkinson’s diseasebotulinum toxinblepharospasmcervical dystonia |
| spellingShingle | Charenya Anandan Charenya Anandan Joseph Jankovic Use of botulinum toxin in the management of dystonia in Parkinson’s disease Frontiers in Neuroscience dystonia Parkinson’s disease botulinum toxin blepharospasm cervical dystonia |
| title | Use of botulinum toxin in the management of dystonia in Parkinson’s disease |
| title_full | Use of botulinum toxin in the management of dystonia in Parkinson’s disease |
| title_fullStr | Use of botulinum toxin in the management of dystonia in Parkinson’s disease |
| title_full_unstemmed | Use of botulinum toxin in the management of dystonia in Parkinson’s disease |
| title_short | Use of botulinum toxin in the management of dystonia in Parkinson’s disease |
| title_sort | use of botulinum toxin in the management of dystonia in parkinson s disease |
| topic | dystonia Parkinson’s disease botulinum toxin blepharospasm cervical dystonia |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1371601/full |
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