Long-Term Effects of ART on the Health of the Offspring
Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/17/13564 |
| _version_ | 1797582413339033600 |
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| author | Hamid Ahmadi Leili Aghebati-Maleki Shima Rashidiani Timea Csabai Obodo Basil Nnaemeka Julia Szekeres-Bartho |
| author_facet | Hamid Ahmadi Leili Aghebati-Maleki Shima Rashidiani Timea Csabai Obodo Basil Nnaemeka Julia Szekeres-Bartho |
| author_sort | Hamid Ahmadi |
| collection | DOAJ |
| description | Assisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences. |
| first_indexed | 2024-03-10T23:20:52Z |
| format | Article |
| id | doaj.art-c4684644d01a4e95b2f5ca1e93bcfe71 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:20:52Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c4684644d01a4e95b2f5ca1e93bcfe712023-11-19T08:19:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124171356410.3390/ijms241713564Long-Term Effects of ART on the Health of the OffspringHamid Ahmadi0Leili Aghebati-Maleki1Shima Rashidiani2Timea Csabai3Obodo Basil Nnaemeka4Julia Szekeres-Bartho5Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, 7624 Pécs, HungaryDepartment of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665931, IranDepartment of Medical Biochemistry, Medical School, Pécs University, 7624 Pécs, HungaryDepartment of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, 7624 Pécs, HungaryDepartment of Laboratory Diagnostics, Faculty of Health Sciences, Pécs University, 7621 Pécs, HungaryDepartment of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pécs University, 7624 Pécs, HungaryAssisted reproductive technologies (ART) significantly increase the chance of successful pregnancy and live birth in infertile couples. The different procedures for ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and gamete intrafallopian tube transfer (GIFT), are widely used to overcome infertility-related problems. In spite of its inarguable usefulness, concerns about the health consequences of ART-conceived babies have been raised. There are reports about the association of ART with birth defects and health complications, e.g., malignancies, high blood pressure, generalized vascular functional disorders, asthma and metabolic disorders in later life. It has been suggested that hormonal treatment of the mother, and the artificial environment during the manipulation of gametes and embryos may cause genomic and epigenetic alterations and subsequent complications in the health status of ART-conceived babies. In the current study, we aimed to review the possible long-term consequences of different ART procedures on the subsequent health status of ART-conceived offspring, considering the confounding factors that might account for/contribute to the long-term consequences.https://www.mdpi.com/1422-0067/24/17/13564ARTstressepigeneticslong-term effects |
| spellingShingle | Hamid Ahmadi Leili Aghebati-Maleki Shima Rashidiani Timea Csabai Obodo Basil Nnaemeka Julia Szekeres-Bartho Long-Term Effects of ART on the Health of the Offspring International Journal of Molecular Sciences ART stress epigenetics long-term effects |
| title | Long-Term Effects of ART on the Health of the Offspring |
| title_full | Long-Term Effects of ART on the Health of the Offspring |
| title_fullStr | Long-Term Effects of ART on the Health of the Offspring |
| title_full_unstemmed | Long-Term Effects of ART on the Health of the Offspring |
| title_short | Long-Term Effects of ART on the Health of the Offspring |
| title_sort | long term effects of art on the health of the offspring |
| topic | ART stress epigenetics long-term effects |
| url | https://www.mdpi.com/1422-0067/24/17/13564 |
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