Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties
Bone substitute materials require specific properties to make them suitable for implantation, such as biocompatibility and resistance to mechanical loads. Mg,Sr-cosubstituted hydroxyapatite (MgSr-HA) is a promising bone scaffold candidate because its structure is similar to the native bone matrix. H...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/11/4930 |
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| author | Elena Landi Stefano Guizzardi Elettra Papa Carlo Galli |
| author_facet | Elena Landi Stefano Guizzardi Elettra Papa Carlo Galli |
| author_sort | Elena Landi |
| collection | DOAJ |
| description | Bone substitute materials require specific properties to make them suitable for implantation, such as biocompatibility and resistance to mechanical loads. Mg,Sr-cosubstituted hydroxyapatite (MgSr-HA) is a promising bone scaffold candidate because its structure is similar to the native bone matrix. However, MgSr-HA materials do not typically withstand thermal treatments over 800 °C, because Mg promotes HA degradation to less stable tricalcium phosphate, a compound that, albeit biocompatible, is not found in bone. We, therefore, designed an ion-exchange process to enrich sintered Sr-HA with Mg and obtain MgSr-HA porous constructs. These materials contained a 0.04–0.08 Mg/Ca molar ratio and a 0.12–0.13 Sr/Ca molar ratio, and had up to 20 MPa of compressive strength, suitable for use as bone fillers or scaffolds. Unlike previous synthetic Mg,Sr-substituted apatite powders, the proposed process did not degrade HA and thus preserved its similarity to bone structure. The obtained material thus combines the presence of bioactive Mg and Sr ions in the HA lattice with a 3D morphological/structural organization that can be customized in pore size and distribution, as well as in mechanical strength, thus potentially covering a wide range of clinical applications. |
| first_indexed | 2024-03-10T10:59:47Z |
| format | Article |
| id | doaj.art-c46bb9cd82de476da0c903007ce82507 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T10:59:47Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-c46bb9cd82de476da0c903007ce825072023-11-21T21:37:19ZengMDPI AGApplied Sciences2076-34172021-05-011111493010.3390/app11114930Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural PropertiesElena Landi0Stefano Guizzardi1Elettra Papa2Carlo Galli3ISTEC-CNR, Institute of Science and Technology for Ceramics-National Research Council, Via Granarolo 64, 48018 Faenza, ItalyDiMeC, Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43126 Parma, ItalyISTEC-CNR, Institute of Science and Technology for Ceramics-National Research Council, Via Granarolo 64, 48018 Faenza, ItalyDiMeC, Department of Medicine and Surgery, University of Parma, Via Volturno 39, 43126 Parma, ItalyBone substitute materials require specific properties to make them suitable for implantation, such as biocompatibility and resistance to mechanical loads. Mg,Sr-cosubstituted hydroxyapatite (MgSr-HA) is a promising bone scaffold candidate because its structure is similar to the native bone matrix. However, MgSr-HA materials do not typically withstand thermal treatments over 800 °C, because Mg promotes HA degradation to less stable tricalcium phosphate, a compound that, albeit biocompatible, is not found in bone. We, therefore, designed an ion-exchange process to enrich sintered Sr-HA with Mg and obtain MgSr-HA porous constructs. These materials contained a 0.04–0.08 Mg/Ca molar ratio and a 0.12–0.13 Sr/Ca molar ratio, and had up to 20 MPa of compressive strength, suitable for use as bone fillers or scaffolds. Unlike previous synthetic Mg,Sr-substituted apatite powders, the proposed process did not degrade HA and thus preserved its similarity to bone structure. The obtained material thus combines the presence of bioactive Mg and Sr ions in the HA lattice with a 3D morphological/structural organization that can be customized in pore size and distribution, as well as in mechanical strength, thus potentially covering a wide range of clinical applications.https://www.mdpi.com/2076-3417/11/11/4930apatite synthesissinteringion exchangeporous scaffoldcharacterization |
| spellingShingle | Elena Landi Stefano Guizzardi Elettra Papa Carlo Galli Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties Applied Sciences apatite synthesis sintering ion exchange porous scaffold characterization |
| title | Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties |
| title_full | Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties |
| title_fullStr | Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties |
| title_full_unstemmed | Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties |
| title_short | Mg,Sr-Cosubstituted Hydroxyapatite with Improved Structural Properties |
| title_sort | mg sr cosubstituted hydroxyapatite with improved structural properties |
| topic | apatite synthesis sintering ion exchange porous scaffold characterization |
| url | https://www.mdpi.com/2076-3417/11/11/4930 |
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