Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved]
Background: Indonesia ranks fifth in terms of the number of stunted children and there has been little change in the stunting prevalence in the last decade. In earlier observational studies conducted in 2014-2015, we identified several key underlying problems with the potential to impact stunting in...
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| Format: | Article |
| Language: | English |
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Wellcome
2022-06-01
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| Series: | Wellcome Open Research |
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| Online Access: | https://wellcomeopenresearch.org/articles/7-167/v1 |
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| author | Dimas Erlangga Luftimas Yenni Zuhairini Suhadi Afini Dwi Purnamasari Haidar Rizqi Mohammad Brachim Ansari Ayunda Jihadillah Aisyah Nur Pratiwi Dearly Ayu Zahrotun Haq Daniela Hampel Samuel Scott Jillian J Haszard Lindsay H Allen Rosalind S Gibson Lisa A Houghton Umi Fahmida Sofa Rahmannia Aly Diana |
| author_facet | Dimas Erlangga Luftimas Yenni Zuhairini Suhadi Afini Dwi Purnamasari Haidar Rizqi Mohammad Brachim Ansari Ayunda Jihadillah Aisyah Nur Pratiwi Dearly Ayu Zahrotun Haq Daniela Hampel Samuel Scott Jillian J Haszard Lindsay H Allen Rosalind S Gibson Lisa A Houghton Umi Fahmida Sofa Rahmannia Aly Diana |
| author_sort | Dimas Erlangga Luftimas |
| collection | DOAJ |
| description | Background: Indonesia ranks fifth in terms of the number of stunted children and there has been little change in the stunting prevalence in the last decade. In earlier observational studies conducted in 2014-2015, we identified several key underlying problems with the potential to impact stunting in Sumedang district, West Java, Indonesia. Deficits in intakes of growth-limiting micronutrients were observed, most notably calcium, iron, zinc, and vitamin A, emphasizing the need for a food-based intervention to overcome these micronutrient deficits in the diets of mothers and their infants. Methods: A double-blind placebo-controlled cluster randomised trial comparing the effect of daily consumption of 75 grams of locally produced micronutrient-enriched crackers (MEC) (intervention group) compared to placebo crackers (control group) by mothers at two-time intervals: (i) from the 8-14 weeks of pregnancy to delivery (i.e., 28-34 weeks of consumption of MEC) on birth length, and (ii) from the 8-14 weeks of pregnancy to 5 months post-partum on attained linear growth and linear growth velocity of breast-fed infants. A total of 324 pregnant women from 28 clusters (villages) located in 3 sub-districts in Sumedang district, West Java, Indonesia, will be randomly assigned to either intervention (n=14 villages) or control (n=14 villages). Discussion: This will be the first study in Indonesia to use crackers based on powdered eggshells and chicken liver, in a form which is acceptable, safe, and has a long shelf life. If daily consumption of MEC for 6 months during pregnancy can enhance birth length, or their continued daily consumption for 5 months postpartum improves both attained and incremental linear growth at 5 months of age, then scaling-up in Indonesia may be considered. Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04564222; 25th September 2020 |
| first_indexed | 2024-04-11T22:10:17Z |
| format | Article |
| id | doaj.art-c46ce739d8024240b1a7da52bc9f3ff4 |
| institution | Directory Open Access Journal |
| issn | 2398-502X |
| language | English |
| last_indexed | 2024-04-11T22:10:17Z |
| publishDate | 2022-06-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj.art-c46ce739d8024240b1a7da52bc9f3ff42022-12-22T04:00:35ZengWellcomeWellcome Open Research2398-502X2022-06-01719804Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved]Dimas Erlangga Luftimas0Yenni Zuhairini Suhadi1Afini Dwi Purnamasari2Haidar Rizqi3Mohammad Brachim Ansari4Ayunda Jihadillah5Aisyah Nur Pratiwi6Dearly Ayu Zahrotun Haq7Daniela Hampel8Samuel Scott9Jillian J Haszard10Lindsay H Allen11Rosalind S Gibson12Lisa A Houghton13Umi Fahmida14Sofa Rahmannia15https://orcid.org/0000-0003-2988-1334Aly Diana16https://orcid.org/0000-0002-9394-5235Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaDepartment of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaDepartment of Nutrition, University of California, One Shields Ave, Davis, 95616, USAPoverty Health and Nutrition Division, International Food Policy Research Institute, Poverty Health and Nutrition Division, New Delhi, 110012, IndiaBiostatistics Centre, University of Otago, Dunedin, 9054, New ZealandDepartment of Nutrition, University of California, One Shields Ave, Davis, 95616, USADepartment of Human Nutrition, University of Otago, Dunedin, 9016, New ZealandDepartment of Human Nutrition, University of Otago, Dunedin, 9016, New ZealandSoutheast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, 13120, IndonesiaFaculty of Medicine, Universitas Pasundan, Bandung, 40117, IndonesiaDepartment of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, IndonesiaBackground: Indonesia ranks fifth in terms of the number of stunted children and there has been little change in the stunting prevalence in the last decade. In earlier observational studies conducted in 2014-2015, we identified several key underlying problems with the potential to impact stunting in Sumedang district, West Java, Indonesia. Deficits in intakes of growth-limiting micronutrients were observed, most notably calcium, iron, zinc, and vitamin A, emphasizing the need for a food-based intervention to overcome these micronutrient deficits in the diets of mothers and their infants. Methods: A double-blind placebo-controlled cluster randomised trial comparing the effect of daily consumption of 75 grams of locally produced micronutrient-enriched crackers (MEC) (intervention group) compared to placebo crackers (control group) by mothers at two-time intervals: (i) from the 8-14 weeks of pregnancy to delivery (i.e., 28-34 weeks of consumption of MEC) on birth length, and (ii) from the 8-14 weeks of pregnancy to 5 months post-partum on attained linear growth and linear growth velocity of breast-fed infants. A total of 324 pregnant women from 28 clusters (villages) located in 3 sub-districts in Sumedang district, West Java, Indonesia, will be randomly assigned to either intervention (n=14 villages) or control (n=14 villages). Discussion: This will be the first study in Indonesia to use crackers based on powdered eggshells and chicken liver, in a form which is acceptable, safe, and has a long shelf life. If daily consumption of MEC for 6 months during pregnancy can enhance birth length, or their continued daily consumption for 5 months postpartum improves both attained and incremental linear growth at 5 months of age, then scaling-up in Indonesia may be considered. Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04564222; 25th September 2020https://wellcomeopenresearch.org/articles/7-167/v1food based intervention Indonesia lactation linear growth micronutrient deficiencies pregnancyeng |
| spellingShingle | Dimas Erlangga Luftimas Yenni Zuhairini Suhadi Afini Dwi Purnamasari Haidar Rizqi Mohammad Brachim Ansari Ayunda Jihadillah Aisyah Nur Pratiwi Dearly Ayu Zahrotun Haq Daniela Hampel Samuel Scott Jillian J Haszard Lindsay H Allen Rosalind S Gibson Lisa A Houghton Umi Fahmida Sofa Rahmannia Aly Diana Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved] Wellcome Open Research food based intervention Indonesia lactation linear growth micronutrient deficiencies pregnancy eng |
| title | Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved] |
| title_full | Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved] |
| title_fullStr | Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved] |
| title_full_unstemmed | Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved] |
| title_short | Chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in Indonesia: a double-blind, randomised placebo-controlled trial (SISTIK Growth Study) [version 1; peer review: 2 approved] |
| title_sort | chicken liver and eggshell crackers as a safe and affordable animal source food for overcoming micronutrient deficits during pregnancy and lactation in indonesia a double blind randomised placebo controlled trial sistik growth study version 1 peer review 2 approved |
| topic | food based intervention Indonesia lactation linear growth micronutrient deficiencies pregnancy eng |
| url | https://wellcomeopenresearch.org/articles/7-167/v1 |
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