The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status

The USP7 Inhibitor P5091 Induces Cell Death in Ovarian Cancers with Different P53 Status

Background/Aims: Ovarian cancer is often diagnosed at later stages with poor prognosis. Recent studies have associated the expression of deubiquitylase USP7 with the survival of ovarian cancers. Being a cysteine protease, USP7 could become a target for pharmacological intervention. Therefore, in thi...

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Main Authors: Mengying Wang, Yayun Zhang, Taishu Wang, Jinrui Zhang, Zhu Zhou, Yan Sun, Shanshan Wang, Yulin Shi, Xuelin Luan, Yingqiu Zhang, Yifei Wang, Yang Wang, Zhongwen Zou, Lan Kang, Han Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
P53
Usp7
P5091
Ovarian cancer
Apoptosis
Targeted therapy
Online Access:https://www.karger.com/Article/FullText/484062

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