Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease
Objectives: In a prospective 4-year study, we evaluated the progression of motor and non-motor symptoms in Parkinson's disease (PD) patients with Asian-specific LRRK2 risk variants and non-carriers.Methods: A total of 202 patients with PD, including 133 risk variant carriers and 69 non-carriers...
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.01379/full |
| _version_ | 1828382527443697664 |
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| author | Xiao Deng Bin Xiao Hui-Hua Li Ebonne Ng Yew-Long Lo Yew-Long Lo Eng-King Tan Eng-King Tan Kumar M. Prakash Kumar M. Prakash |
| author_facet | Xiao Deng Bin Xiao Hui-Hua Li Ebonne Ng Yew-Long Lo Yew-Long Lo Eng-King Tan Eng-King Tan Kumar M. Prakash Kumar M. Prakash |
| author_sort | Xiao Deng |
| collection | DOAJ |
| description | Objectives: In a prospective 4-year study, we evaluated the progression of motor and non-motor symptoms in Parkinson's disease (PD) patients with Asian-specific LRRK2 risk variants and non-carriers.Methods: A total of 202 patients with PD, including 133 risk variant carriers and 69 non-carriers, were followed up and evaluated using the Modified Hoehn and Yahr staging scale, Unified Parkinson's Disease Rating Scale part III, Non-motor Symptom Scale, Parkinson's disease Questionnaire-39 item version. Means of generalized estimating equation model was performed to compare the differences from baseline between LRRK2 risk variant carriers and non-carriers.Results: Our longitudinal analysis revealed that risk variant carriers exhibited greater progression than non-carriers after 4 years based on the modified Hoehn and Yahr staging scale (risk variants carriers, 0.65; non-carriers, 0.06; P = 0.041). Meanwhile, Unified Parkinson's Disease Rating Scale gait and posture score in risk variant carriers also showed greater increase than that in non-carriers, although the difference was not statistically significant. Non-carriers experienced a transient improvement in non-motor symptoms at the early stage of PD, as scores at visit two significantly reduced compared to baseline in Non-motor Symptom Scale domain 3 (mood/apathy), Parkinson's disease Questionnaire-39 item version domain 3 (emotional well-being), and frequency of NMS in non-carriers but not in risk variants carriers.Conclusions: PD gene risk variant carriers were more likely to progress faster in their motor severity than non-carriers. There were transient differences in certain non-motor symptoms and quality of life in carriers. However, more studies are warranted to assess the association of PD risk variants and progression of non-motor symptoms. |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T04:33:21Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-c46f81165a994dafba4e7c0d5f4d7af72022-12-22T02:02:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-01-011010.3389/fneur.2019.01379473559Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's DiseaseXiao Deng0Bin Xiao1Hui-Hua Li2Ebonne Ng3Yew-Long Lo4Yew-Long Lo5Eng-King Tan6Eng-King Tan7Kumar M. Prakash8Kumar M. Prakash9Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, SingaporeDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, SingaporeHealth Services Research Unit, Singapore General Hospital, Singapore, SingaporeDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, SingaporeDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, SingaporeSignature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, SingaporeDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, SingaporeSignature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, SingaporeDepartment of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, SingaporeSignature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore, SingaporeObjectives: In a prospective 4-year study, we evaluated the progression of motor and non-motor symptoms in Parkinson's disease (PD) patients with Asian-specific LRRK2 risk variants and non-carriers.Methods: A total of 202 patients with PD, including 133 risk variant carriers and 69 non-carriers, were followed up and evaluated using the Modified Hoehn and Yahr staging scale, Unified Parkinson's Disease Rating Scale part III, Non-motor Symptom Scale, Parkinson's disease Questionnaire-39 item version. Means of generalized estimating equation model was performed to compare the differences from baseline between LRRK2 risk variant carriers and non-carriers.Results: Our longitudinal analysis revealed that risk variant carriers exhibited greater progression than non-carriers after 4 years based on the modified Hoehn and Yahr staging scale (risk variants carriers, 0.65; non-carriers, 0.06; P = 0.041). Meanwhile, Unified Parkinson's Disease Rating Scale gait and posture score in risk variant carriers also showed greater increase than that in non-carriers, although the difference was not statistically significant. Non-carriers experienced a transient improvement in non-motor symptoms at the early stage of PD, as scores at visit two significantly reduced compared to baseline in Non-motor Symptom Scale domain 3 (mood/apathy), Parkinson's disease Questionnaire-39 item version domain 3 (emotional well-being), and frequency of NMS in non-carriers but not in risk variants carriers.Conclusions: PD gene risk variant carriers were more likely to progress faster in their motor severity than non-carriers. There were transient differences in certain non-motor symptoms and quality of life in carriers. However, more studies are warranted to assess the association of PD risk variants and progression of non-motor symptoms.https://www.frontiersin.org/article/10.3389/fneur.2019.01379/fullParkinson's diseaseprogressionLRRK2motornon-motor |
| spellingShingle | Xiao Deng Bin Xiao Hui-Hua Li Ebonne Ng Yew-Long Lo Yew-Long Lo Eng-King Tan Eng-King Tan Kumar M. Prakash Kumar M. Prakash Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease Frontiers in Neurology Parkinson's disease progression LRRK2 motor non-motor |
| title | Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease |
| title_full | Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease |
| title_fullStr | Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease |
| title_full_unstemmed | Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease |
| title_short | Four-Year Longitudinal Study of Motor and Non-motor Symptoms in LRRK2-Related Parkinson's Disease |
| title_sort | four year longitudinal study of motor and non motor symptoms in lrrk2 related parkinson s disease |
| topic | Parkinson's disease progression LRRK2 motor non-motor |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.01379/full |
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