Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients
Abstract Idiopathic tinnitus is a common and complex disorder with no established cure. The CAABT (Cochleural Alternating Acoustic Beam Therapy CAABT), is a personalized sound therapy designed to target specific tinnitus frequencies and effectively intervene in tinnitus according to clinical tinnitu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55866-0 |
| _version_ | 1797259378297929728 |
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| author | Chunli Liu Jie Zhang Zhiwei Qi Wenhui Yue Yujie Yuan Tao Jiang Shenglin Zhang Shujun Zhang |
| author_facet | Chunli Liu Jie Zhang Zhiwei Qi Wenhui Yue Yujie Yuan Tao Jiang Shenglin Zhang Shujun Zhang |
| author_sort | Chunli Liu |
| collection | DOAJ |
| description | Abstract Idiopathic tinnitus is a common and complex disorder with no established cure. The CAABT (Cochleural Alternating Acoustic Beam Therapy CAABT), is a personalized sound therapy designed to target specific tinnitus frequencies and effectively intervene in tinnitus according to clinical tinnitus assessment. This study aimed to compare the effectiveness of the CAABT and Traditional Sound Therapy (TST) in managing chronic idiopathic tinnitus. This was a randomized, double-blind, parallel-group, single-center prospective study. Sixty adult patients with tinnitus were recruited and randomly assigned to the CAABT or TST group in a 1:1 ratio using a computer-generated randomization. The treatment lasted for 12 weeks, and participants underwent assessments using the tinnitus handicap inventory (THI), visual analog scale (VAS), tinnitus loudness measurements, and resting-state functional magnetic resonance imaging (rs-fMRI). Both groups showed significant reductions in THI scores, VAS scores, and tinnitus loudness after treatment. However, CAABT showed superiority to TST in THI Functional (p = 0.018), THI Emotional (p = 0.015), THI Catastrophic (p = 0.022), THI total score (p = 0.005) as well as VAS score (p = 0.022). More interesting, CAABT showed superiority to TST in the changes of THI scores, and VAS scores from baseline. The rs-fMRI results showed significant changes in the precuneus before and after treatment in both groups. Moreover, the CAABT group showed more changes in brain regions compared to the TST. No side effects were observed. These findings suggest that CAABT may be a promising treatment option for chronic idiopathic tinnitus, providing significant improvements in tinnitus-related symptoms and brain activity. Trial registration: ClinicalTrials.gov:NCT02774122. |
| first_indexed | 2024-04-24T23:08:28Z |
| format | Article |
| id | doaj.art-c47010f85439498e90c5c50165531203 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:08:28Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-c47010f85439498e90c5c501655312032024-03-17T12:22:19ZengNature PortfolioScientific Reports2045-23222024-03-0114111310.1038/s41598-024-55866-0Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patientsChunli Liu0Jie Zhang1Zhiwei Qi2Wenhui Yue3Yujie Yuan4Tao Jiang5Shenglin Zhang6Shujun Zhang7Department of Otolaryngology, The Affiliated Hospital of Chengde Medical CollegeDepartment of Otolaryngology, The Affiliated Hospital of Chengde Medical CollegeDepartment of Otolaryngology, The Affiliated Hospital of Chengde Medical CollegeDepartment of Otolaryngology, The Affiliated Hospital of Chengde Medical CollegeDepartment of Otolaryngology, The Affiliated Hospital of Chengde Medical CollegeThe Labs of Micro-DSP Technology LTDDepartment of Oncology, The Affiliated Hospital of Chengde Medical CollegeDepartment of Otolaryngology, The Affiliated Hospital of Chengde Medical CollegeAbstract Idiopathic tinnitus is a common and complex disorder with no established cure. The CAABT (Cochleural Alternating Acoustic Beam Therapy CAABT), is a personalized sound therapy designed to target specific tinnitus frequencies and effectively intervene in tinnitus according to clinical tinnitus assessment. This study aimed to compare the effectiveness of the CAABT and Traditional Sound Therapy (TST) in managing chronic idiopathic tinnitus. This was a randomized, double-blind, parallel-group, single-center prospective study. Sixty adult patients with tinnitus were recruited and randomly assigned to the CAABT or TST group in a 1:1 ratio using a computer-generated randomization. The treatment lasted for 12 weeks, and participants underwent assessments using the tinnitus handicap inventory (THI), visual analog scale (VAS), tinnitus loudness measurements, and resting-state functional magnetic resonance imaging (rs-fMRI). Both groups showed significant reductions in THI scores, VAS scores, and tinnitus loudness after treatment. However, CAABT showed superiority to TST in THI Functional (p = 0.018), THI Emotional (p = 0.015), THI Catastrophic (p = 0.022), THI total score (p = 0.005) as well as VAS score (p = 0.022). More interesting, CAABT showed superiority to TST in the changes of THI scores, and VAS scores from baseline. The rs-fMRI results showed significant changes in the precuneus before and after treatment in both groups. Moreover, the CAABT group showed more changes in brain regions compared to the TST. No side effects were observed. These findings suggest that CAABT may be a promising treatment option for chronic idiopathic tinnitus, providing significant improvements in tinnitus-related symptoms and brain activity. Trial registration: ClinicalTrials.gov:NCT02774122.https://doi.org/10.1038/s41598-024-55866-0Cochleural alternating acoustic beam therapySound therapyChronic idiopathic tinnitusRandomized controlled clinical trial |
| spellingShingle | Chunli Liu Jie Zhang Zhiwei Qi Wenhui Yue Yujie Yuan Tao Jiang Shenglin Zhang Shujun Zhang Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients Scientific Reports Cochleural alternating acoustic beam therapy Sound therapy Chronic idiopathic tinnitus Randomized controlled clinical trial |
| title | Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients |
| title_full | Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients |
| title_fullStr | Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients |
| title_full_unstemmed | Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients |
| title_short | Therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients |
| title_sort | therapy effect of cochleural alternating acoustic beam therapy versus traditional sound therapy for managing chronic idiopathic tinnitus patients |
| topic | Cochleural alternating acoustic beam therapy Sound therapy Chronic idiopathic tinnitus Randomized controlled clinical trial |
| url | https://doi.org/10.1038/s41598-024-55866-0 |
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