Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning
Extracorporeal removal of organophosphate from blood has been proposed, but the efficacy of hemodialysis and hemoperfusion has not been established. We report a case of organophosphate poisoning in which continuous renal replacement therapy (CRRT) was applied with conventional indications and was fo...
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| Format: | Article |
| Language: | English |
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Korean Society of Critical Care Medicine
2022-11-01
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| Series: | Acute and Critical Care |
| Subjects: | |
| Online Access: | http://www.accjournal.org/upload/pdf/acc-2021-00780.pdf |
| _version_ | 1811293481866362880 |
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| author | In Ho Kwon Jinwoo Jeong Yuri Choi |
| author_facet | In Ho Kwon Jinwoo Jeong Yuri Choi |
| author_sort | In Ho Kwon |
| collection | DOAJ |
| description | Extracorporeal removal of organophosphate from blood has been proposed, but the efficacy of hemodialysis and hemoperfusion has not been established. We report a case of organophosphate poisoning in which continuous renal replacement therapy (CRRT) was applied with conventional indications and was found to increase plasma cholinesterase levels by hemodiafiltration. A 73-year-old male was found unconscious at home and was brought to the emergency department by ambulance. An empty bottle of Supracide insecticide, of which the active ingredient is methidathion, was found beside him. CRRT was initiated because he showed signs of oliguria and acidosis with an unstable hemodynamic condition. Although his condition improved temporarily after CRRT initiation, it subsequently deteriorated, and he died despite maximal supportive effort. His prefilter plasma cholinesterase levels remained at <200 U/L for 3 days, while his postfilter levels were 358 U/L 1 hour after CRRT initiation and they were 689 U/L 18 hours later. Our case suggests that CRRT might play a role in treating organophosphate poisoning by possibly eliminating organophosphate. |
| first_indexed | 2024-04-13T05:02:03Z |
| format | Article |
| id | doaj.art-c4702cecacd543a98fdaa30a55009a43 |
| institution | Directory Open Access Journal |
| issn | 2586-6052 2586-6060 |
| language | English |
| last_indexed | 2024-04-13T05:02:03Z |
| publishDate | 2022-11-01 |
| publisher | Korean Society of Critical Care Medicine |
| record_format | Article |
| series | Acute and Critical Care |
| spelling | doaj.art-c4702cecacd543a98fdaa30a55009a432022-12-22T03:01:17ZengKorean Society of Critical Care MedicineAcute and Critical Care2586-60522586-60602022-11-0137466967110.4266/acc.2021.007801319Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoningIn Ho Kwon0Jinwoo Jeong1Yuri Choi2 Department of Emergency Medicine, Dong-A University College of Medicine, Busan, Korea Department of Emergency Medicine, Dong-A University College of Medicine, Busan, Korea Department of Emergency Medicine, Dong-A University College of Medicine, Busan, KoreaExtracorporeal removal of organophosphate from blood has been proposed, but the efficacy of hemodialysis and hemoperfusion has not been established. We report a case of organophosphate poisoning in which continuous renal replacement therapy (CRRT) was applied with conventional indications and was found to increase plasma cholinesterase levels by hemodiafiltration. A 73-year-old male was found unconscious at home and was brought to the emergency department by ambulance. An empty bottle of Supracide insecticide, of which the active ingredient is methidathion, was found beside him. CRRT was initiated because he showed signs of oliguria and acidosis with an unstable hemodynamic condition. Although his condition improved temporarily after CRRT initiation, it subsequently deteriorated, and he died despite maximal supportive effort. His prefilter plasma cholinesterase levels remained at <200 U/L for 3 days, while his postfilter levels were 358 U/L 1 hour after CRRT initiation and they were 689 U/L 18 hours later. Our case suggests that CRRT might play a role in treating organophosphate poisoning by possibly eliminating organophosphate.http://www.accjournal.org/upload/pdf/acc-2021-00780.pdfcholinesterasecontinuous renal replacement therapydecontaminationorganophosphate poisoning |
| spellingShingle | In Ho Kwon Jinwoo Jeong Yuri Choi Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning Acute and Critical Care cholinesterase continuous renal replacement therapy decontamination organophosphate poisoning |
| title | Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning |
| title_full | Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning |
| title_fullStr | Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning |
| title_full_unstemmed | Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning |
| title_short | Continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning |
| title_sort | continuous renal replacement therapy increased plasma cholinesterase activity in a case of acute organophosphate poisoning |
| topic | cholinesterase continuous renal replacement therapy decontamination organophosphate poisoning |
| url | http://www.accjournal.org/upload/pdf/acc-2021-00780.pdf |
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