8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria
DNA in human’s sperm is located in nucleus (nDNA) and mitochondria (mtDNA). DNA oxidation is indicated from high concentrationof 8-OH-dG. It is very important to identify factors that can cause genetic dysfunction risk responsible for genetic changes. 8-OH-dGcompound are a promutagenic of DNA dysf...
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Biological Society
2012-02-01
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| Series: | Journal of Biological Researches |
| Subjects: | |
| Online Access: | http://berkalahayati.org/journal/bcdf75ad |
| _version_ | 1819134935356669952 |
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| author | Sudjarwo Sudjarwo |
| author_facet | Sudjarwo Sudjarwo |
| author_sort | Sudjarwo Sudjarwo |
| collection | DOAJ |
| description | DNA in human’s sperm is located in nucleus (nDNA) and mitochondria (mtDNA). DNA oxidation is indicated from high concentrationof 8-OH-dG. It is very important to identify factors that can cause genetic dysfunction risk responsible for genetic changes. 8-OH-dGcompound are a promutagenic of DNA dysfunction of deoxyguanosine oxidation by oxygen radical. ROS is an oxidation, which in highconcentration can oxidize DNA. Guanine is a nucleotide, which prone to oxidation, with 8-OH-dG as the end product. Detection of 8-OH-dG can be done by HPLC method. These results indicated that there were significant differences (p < 0.01) in detection of 8-OHdGin sperm, between normospermia with asthenospermia and normospermia with oligospermia. Correlation (r) of 8-OH-dG withmotile spermatozoa is – 0.7111. Immotile spermatozoa caused by oxidation or DNA damage are shown by high concentration of 8-OHdG.In normal physical condition, sperm produces oxidant. High oxidant is toxic to sperm, which influence their motility. Sperm’s motilityis one of factors causing male infertility. |
| first_indexed | 2024-12-22T10:11:05Z |
| format | Article |
| id | doaj.art-c470306f30454c3c93485fb4cd07ea77 |
| institution | Directory Open Access Journal |
| issn | 0852-6834 2337-389X |
| language | English |
| last_indexed | 2024-12-22T10:11:05Z |
| publishDate | 2012-02-01 |
| publisher | Indonesian Biological Society |
| record_format | Article |
| series | Journal of Biological Researches |
| spelling | doaj.art-c470306f30454c3c93485fb4cd07ea772022-12-21T18:29:52ZengIndonesian Biological SocietyJournal of Biological Researches0852-68342337-389X2012-02-01101434710.23869/bphjbr.10.1.200488-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas priaSudjarwo Sudjarwo0Fakultas Farmasi Universitas AirlanggaDNA in human’s sperm is located in nucleus (nDNA) and mitochondria (mtDNA). DNA oxidation is indicated from high concentrationof 8-OH-dG. It is very important to identify factors that can cause genetic dysfunction risk responsible for genetic changes. 8-OH-dGcompound are a promutagenic of DNA dysfunction of deoxyguanosine oxidation by oxygen radical. ROS is an oxidation, which in highconcentration can oxidize DNA. Guanine is a nucleotide, which prone to oxidation, with 8-OH-dG as the end product. Detection of 8-OH-dG can be done by HPLC method. These results indicated that there were significant differences (p < 0.01) in detection of 8-OHdGin sperm, between normospermia with asthenospermia and normospermia with oligospermia. Correlation (r) of 8-OH-dG withmotile spermatozoa is – 0.7111. Immotile spermatozoa caused by oxidation or DNA damage are shown by high concentration of 8-OHdG.In normal physical condition, sperm produces oxidant. High oxidant is toxic to sperm, which influence their motility. Sperm’s motilityis one of factors causing male infertility.http://berkalahayati.org/journal/bcdf75ad8-hydroxydeoxyguanosinesperm motilitymale infertility |
| spellingShingle | Sudjarwo Sudjarwo 8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria Journal of Biological Researches 8-hydroxydeoxyguanosine sperm motility male infertility |
| title | 8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria |
| title_full | 8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria |
| title_fullStr | 8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria |
| title_full_unstemmed | 8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria |
| title_short | 8-Hidroksi-deoksiguanosin sebagai salah satu indikator infertilitas pria |
| title_sort | 8 hidroksi deoksiguanosin sebagai salah satu indikator infertilitas pria |
| topic | 8-hydroxydeoxyguanosine sperm motility male infertility |
| url | http://berkalahayati.org/journal/bcdf75ad |
| work_keys_str_mv | AT sudjarwosudjarwo 8hidroksideoksiguanosinsebagaisalahsatuindikatorinfertilitaspria |