Intercellular Adhesion Molecule-1 as Target for CAR-T-Cell Therapy of Triple-Negative Breast Cancer

Intercellular Adhesion Molecule-1 as Target for CAR-T-Cell Therapy of Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) comprises lethal malignancies with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy is an effective immunotherapeutic strategy that has demonstrated unprecedented efficacy in the treatment of hematological malignancies but has shown lim...

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Bibliographic Details
Main Authors: Heng Wei, Zeng Wang, Yi Kuang, Zhiguo Wu, Shasha Zhao, Zongliang Zhang, Hexian Li, Meijun Zheng, Nan Zhang, Cheng Long, Wenhao Guo, Chunlai Nie, Hui Yang, Aiping Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
triple-negative breast cancer
intercellular adhesion molecule-1
chimeric antigen receptor T cells
immunotherapy
single chain variable fragment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.573823/full

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