Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?

Are Multiple Mitochondrial Related Signalling Pathways Involved in Carotid Body Oxygen Sensing?

It is generally acknowledged that the carotid body (CB) type I cell mitochondria are unique, being inhibited by relatively small falls in PaO2 well above those known to inhibit electron transport in other cell types. This feature is suggested to allow for the CB to function as an acute O2 sensor, be...

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Bibliographic Details
Main Authors: Andrew P. Holmes, Agnieszka Swiderska, Demitris Nathanael, Hayyaf S. Aldossary, Clare J. Ray, Andrew M. Coney, Prem Kumar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Physiology
Subjects:
carotid body
hypoxia
mitochondria
succinate
arterial chemoreceptor
O2 sensor
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.908617/full

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