Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells.
Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that thes...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5135100?pdf=render |
| _version_ | 1828962706620678144 |
|---|---|
| author | Miriam Fernandez-Gallardo Ricardo González-Ramírez Alejandro Sandoval Ricardo Felix Eduardo Monjaraz |
| author_facet | Miriam Fernandez-Gallardo Ricardo González-Ramírez Alejandro Sandoval Ricardo Felix Eduardo Monjaraz |
| author_sort | Miriam Fernandez-Gallardo |
| collection | DOAJ |
| description | Emerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that these effects depend on the activation of the A2B receptor, which then triggers an intracellular response mediated by the adenylate cyclase/PKA/cAMP signaling pathway. Ado also increases the expression of NaV1.5 channels, a potential biomarker in breast cancer. Together, these data suggest important roles of the A2B receptors and NaV1.5 channels in the Ado-induced increase in proliferation and migration of the MDA-MB 231 cells. |
| first_indexed | 2024-12-14T10:09:39Z |
| format | Article |
| id | doaj.art-c4752f4870f346b199b34ce64775e66b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T10:09:39Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c4752f4870f346b199b34ce64775e66b2022-12-21T23:07:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011112e016744510.1371/journal.pone.0167445Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells.Miriam Fernandez-GallardoRicardo González-RamírezAlejandro SandovalRicardo FelixEduardo MonjarazEmerging evidence suggests that the adenosine (Ado) receptors may play crucial roles in tumor progression. Here, we show that Ado increases proliferation and migration in a triple negative breast cancer model, the MDA-MB 231 cell line. The use of specific agonists and antagonists evidenced that these effects depend on the activation of the A2B receptor, which then triggers an intracellular response mediated by the adenylate cyclase/PKA/cAMP signaling pathway. Ado also increases the expression of NaV1.5 channels, a potential biomarker in breast cancer. Together, these data suggest important roles of the A2B receptors and NaV1.5 channels in the Ado-induced increase in proliferation and migration of the MDA-MB 231 cells.http://europepmc.org/articles/PMC5135100?pdf=render |
| spellingShingle | Miriam Fernandez-Gallardo Ricardo González-Ramírez Alejandro Sandoval Ricardo Felix Eduardo Monjaraz Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells. PLoS ONE |
| title | Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells. |
| title_full | Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells. |
| title_fullStr | Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells. |
| title_full_unstemmed | Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells. |
| title_short | Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells. |
| title_sort | adenosine stimulate proliferation and migration in triple negative breast cancer cells |
| url | http://europepmc.org/articles/PMC5135100?pdf=render |
| work_keys_str_mv | AT miriamfernandezgallardo adenosinestimulateproliferationandmigrationintriplenegativebreastcancercells AT ricardogonzalezramirez adenosinestimulateproliferationandmigrationintriplenegativebreastcancercells AT alejandrosandoval adenosinestimulateproliferationandmigrationintriplenegativebreastcancercells AT ricardofelix adenosinestimulateproliferationandmigrationintriplenegativebreastcancercells AT eduardomonjaraz adenosinestimulateproliferationandmigrationintriplenegativebreastcancercells |