Extracellular vesicles derived from different sources play various roles in diabetic retinopathy
Extracellular vesicles (EVs) are present in almost all biological fluids and secreted by almost all cell types. A growing number of studies have revealed the potential roles of EVs in the diagnosis and treatment of the diabetic retinopathy (DR). Changes in the quantity and content of EVs may serve a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1064415/full |
| _version_ | 1797961805998325760 |
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| author | Tingting Chen Fang Wang Jiayi Wei Le Feng |
| author_facet | Tingting Chen Fang Wang Jiayi Wei Le Feng |
| author_sort | Tingting Chen |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are present in almost all biological fluids and secreted by almost all cell types. A growing number of studies have revealed the potential roles of EVs in the diagnosis and treatment of the diabetic retinopathy (DR). Changes in the quantity and content of EVs may serve as biomarkers of cause or consequence of pathological status of DR, such as inflammation, neovascularization and epithelial-mesenchymal transition. In addition, as natural, safe and efficient drug carrier, EVs have been reported to play important roles in intercellular communication by acting for essential cell-specific information to target cells. In this review, we summarize the roles of EVs, secreted by various types of cells and participated in various biological processes, in the pathogenesis, diagnosis, and treatment of DR. |
| first_indexed | 2024-04-11T01:03:31Z |
| format | Article |
| id | doaj.art-c4767690151e45e3b17a1ac2c638aa72 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T01:03:31Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-c4767690151e45e3b17a1ac2c638aa722023-01-04T14:34:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-01-011310.3389/fendo.2022.10644151064415Extracellular vesicles derived from different sources play various roles in diabetic retinopathyTingting ChenFang WangJiayi WeiLe FengExtracellular vesicles (EVs) are present in almost all biological fluids and secreted by almost all cell types. A growing number of studies have revealed the potential roles of EVs in the diagnosis and treatment of the diabetic retinopathy (DR). Changes in the quantity and content of EVs may serve as biomarkers of cause or consequence of pathological status of DR, such as inflammation, neovascularization and epithelial-mesenchymal transition. In addition, as natural, safe and efficient drug carrier, EVs have been reported to play important roles in intercellular communication by acting for essential cell-specific information to target cells. In this review, we summarize the roles of EVs, secreted by various types of cells and participated in various biological processes, in the pathogenesis, diagnosis, and treatment of DR.https://www.frontiersin.org/articles/10.3389/fendo.2022.1064415/fulldiabetic retinopathyextracellular vesicles (EVs)exosomesbiomarkertreatment |
| spellingShingle | Tingting Chen Fang Wang Jiayi Wei Le Feng Extracellular vesicles derived from different sources play various roles in diabetic retinopathy Frontiers in Endocrinology diabetic retinopathy extracellular vesicles (EVs) exosomes biomarker treatment |
| title | Extracellular vesicles derived from different sources play various roles in diabetic retinopathy |
| title_full | Extracellular vesicles derived from different sources play various roles in diabetic retinopathy |
| title_fullStr | Extracellular vesicles derived from different sources play various roles in diabetic retinopathy |
| title_full_unstemmed | Extracellular vesicles derived from different sources play various roles in diabetic retinopathy |
| title_short | Extracellular vesicles derived from different sources play various roles in diabetic retinopathy |
| title_sort | extracellular vesicles derived from different sources play various roles in diabetic retinopathy |
| topic | diabetic retinopathy extracellular vesicles (EVs) exosomes biomarker treatment |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1064415/full |
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