C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response
Mitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells’ progression and determine immune cells’ fate. Complement C1q binding protein (C1QBP) plays an indispensable role through regulating mitochondrial morphology, metab...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1012112/full |
| _version_ | 1797988296435957760 |
|---|---|
| author | Qiping Wang Dafei Chai Navid Sobhani Nan Sun Nan Sun Nan Sun Praveen Neeli Junnian Zheng Junnian Zheng Hui Tian Hui Tian Hui Tian |
| author_facet | Qiping Wang Dafei Chai Navid Sobhani Nan Sun Nan Sun Nan Sun Praveen Neeli Junnian Zheng Junnian Zheng Hui Tian Hui Tian Hui Tian |
| author_sort | Qiping Wang |
| collection | DOAJ |
| description | Mitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells’ progression and determine immune cells’ fate. Complement C1q binding protein (C1QBP) plays an indispensable role through regulating mitochondrial morphology, metabolism, and autophagy. C1QBP promotes mitochondrial plasticity to impact tumor metastasis and their therapeutic response. At the same time, C1QBP is involved in regulating immune cells’ maturation, differentiation, and effector function through the enhancement of mitochondrial function. In this regard, manipulation of C1QBP has been shown to adjust the competitive balance between tumor cells and immune cells. In the course of evolution, mitochondrial plasticity has endowed numerous advantages against the relentless microenvironment of tumors. In this current review, we summarize the current knowledge of the mechanism of C1QBP regulation of cancer and immunity. We explain this process in vision of potentially new anticancer therapies. |
| first_indexed | 2024-04-11T08:01:56Z |
| format | Article |
| id | doaj.art-c4772cee5ab54c909543bd132e7cfe3c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T08:01:56Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-c4772cee5ab54c909543bd132e7cfe3c2022-12-22T04:35:42ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-11-011310.3389/fphys.2022.10121121012112C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune responseQiping Wang0Dafei Chai1Navid Sobhani2Nan Sun3Nan Sun4Nan Sun5Praveen Neeli6Junnian Zheng7Junnian Zheng8Hui Tian9Hui Tian10Hui Tian11Jiangyin Clinical Medical College, Jiangsu University, Jiangyin, Jiangsu, ChinaDepartment of Medicine, Baylor College of Medicine, Houston, TX, United StatesDepartment of Medicine, Baylor College of Medicine, Houston, TX, United StatesCancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaCenter of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Medicine, Baylor College of Medicine, Houston, TX, United StatesCenter of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaCancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaCenter of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, ChinaJiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaMitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells’ progression and determine immune cells’ fate. Complement C1q binding protein (C1QBP) plays an indispensable role through regulating mitochondrial morphology, metabolism, and autophagy. C1QBP promotes mitochondrial plasticity to impact tumor metastasis and their therapeutic response. At the same time, C1QBP is involved in regulating immune cells’ maturation, differentiation, and effector function through the enhancement of mitochondrial function. In this regard, manipulation of C1QBP has been shown to adjust the competitive balance between tumor cells and immune cells. In the course of evolution, mitochondrial plasticity has endowed numerous advantages against the relentless microenvironment of tumors. In this current review, we summarize the current knowledge of the mechanism of C1QBP regulation of cancer and immunity. We explain this process in vision of potentially new anticancer therapies.https://www.frontiersin.org/articles/10.3389/fphys.2022.1012112/fullC1QBPmitochondrial plasticitymetabolic flexibilitytumor progressionantitumor immune responseimmunotherapy |
| spellingShingle | Qiping Wang Dafei Chai Navid Sobhani Nan Sun Nan Sun Nan Sun Praveen Neeli Junnian Zheng Junnian Zheng Hui Tian Hui Tian Hui Tian C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response Frontiers in Physiology C1QBP mitochondrial plasticity metabolic flexibility tumor progression antitumor immune response immunotherapy |
| title | C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response |
| title_full | C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response |
| title_fullStr | C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response |
| title_full_unstemmed | C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response |
| title_short | C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response |
| title_sort | c1qbp regulates mitochondrial plasticity to impact tumor progression and antitumor immune response |
| topic | C1QBP mitochondrial plasticity metabolic flexibility tumor progression antitumor immune response immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1012112/full |
| work_keys_str_mv | AT qipingwang c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT dafeichai c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT navidsobhani c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT nansun c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT nansun c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT nansun c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT praveenneeli c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT junnianzheng c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT junnianzheng c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT huitian c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT huitian c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse AT huitian c1qbpregulatesmitochondrialplasticitytoimpacttumorprogressionandantitumorimmuneresponse |