Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019
In patients affected by Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD) and Coronavirus Disease 2019 (COVID-19), unclear mechanisms negatively interfere with the hematopoietic response to hypoxia. Although stimulated by physiological hypoxia, pulmonary hypoxi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/9/1460 |
| _version_ | 1797520413971972096 |
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| author | Lorena Duca Sara Ottolenghi Silvia Coppola Rocco Rinaldo Michele Dei Cas Federico Maria Rubino Rita Paroni Michele Samaja Davide Alberto Chiumello Irene Motta |
| author_facet | Lorena Duca Sara Ottolenghi Silvia Coppola Rocco Rinaldo Michele Dei Cas Federico Maria Rubino Rita Paroni Michele Samaja Davide Alberto Chiumello Irene Motta |
| author_sort | Lorena Duca |
| collection | DOAJ |
| description | In patients affected by Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD) and Coronavirus Disease 2019 (COVID-19), unclear mechanisms negatively interfere with the hematopoietic response to hypoxia. Although stimulated by physiological hypoxia, pulmonary hypoxic patients usually develop anemia, which may ultimately complicate the outcome. To characterize this non-adaptive response, we dissected the interplay among the redox state, iron regulation, and inflammation in patients challenged by either acute (ARDS and COVID-19) or chronic (COPD) hypoxia. To this purpose, we evaluated a panel of redox state biomarkers that may integrate the routine iron metabolism assays to monitor the patients’ inflammatory and oxidative state. We measured redox and hematopoietic regulators in 20 ARDS patients, 20 ambulatory COPD patients, 9 COVID-19 ARDS-like patients, and 10 age-matched non-hypoxic healthy volunteers (controls). All the examined pathological conditions induced hypoxia, with ARDS and COVID-19 depressing the hematopoietic response without remarkable effects on erythropoietin. Free iron was higher than the controls in all patients, with higher levels of hepcidin and soluble transferrin receptor in ARDS and COVID-19. All markers of the redox state and antioxidant barrier were overexpressed in ARDS and COVID-19. However, glutathionyl hemoglobin, a candidate marker for the redox imbalance, was especially low in ARDS, despite depressed levels of glutathione being present in all patients. Although iron regulation was dysfunctional in all groups, the depressed antioxidant barrier in ARDS, and to a lesser extent in COVID-19, might induce greater inflammatory responses with consequent anemia. |
| first_indexed | 2024-03-10T07:56:26Z |
| format | Article |
| id | doaj.art-c47790d9e5dc4533b57386d99d42f738 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T07:56:26Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c47790d9e5dc4533b57386d99d42f7382023-11-22T11:49:06ZengMDPI AGAntioxidants2076-39212021-09-01109146010.3390/antiox10091460Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019Lorena Duca0Sara Ottolenghi1Silvia Coppola2Rocco Rinaldo3Michele Dei Cas4Federico Maria Rubino5Rita Paroni6Michele Samaja7Davide Alberto Chiumello8Irene Motta9General Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, 20142 Milan, ItalyDepartment of Anesthesia and Intensive Care, ASST Santi Paolo e Carlo, 20142 Milan, ItalyRespiratory Unit, ASST Santi Paolo e Carlo, 20142 Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, 20142 Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, 20142 Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, 20142 Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, 20142 Milan, ItalyDepartment of Health Sciences, Università degli Studi di Milano, 20142 Milan, ItalyGeneral Medicine Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyIn patients affected by Acute Respiratory Distress Syndrome (ARDS), Chronic Obstructive Pulmonary Disease (COPD) and Coronavirus Disease 2019 (COVID-19), unclear mechanisms negatively interfere with the hematopoietic response to hypoxia. Although stimulated by physiological hypoxia, pulmonary hypoxic patients usually develop anemia, which may ultimately complicate the outcome. To characterize this non-adaptive response, we dissected the interplay among the redox state, iron regulation, and inflammation in patients challenged by either acute (ARDS and COVID-19) or chronic (COPD) hypoxia. To this purpose, we evaluated a panel of redox state biomarkers that may integrate the routine iron metabolism assays to monitor the patients’ inflammatory and oxidative state. We measured redox and hematopoietic regulators in 20 ARDS patients, 20 ambulatory COPD patients, 9 COVID-19 ARDS-like patients, and 10 age-matched non-hypoxic healthy volunteers (controls). All the examined pathological conditions induced hypoxia, with ARDS and COVID-19 depressing the hematopoietic response without remarkable effects on erythropoietin. Free iron was higher than the controls in all patients, with higher levels of hepcidin and soluble transferrin receptor in ARDS and COVID-19. All markers of the redox state and antioxidant barrier were overexpressed in ARDS and COVID-19. However, glutathionyl hemoglobin, a candidate marker for the redox imbalance, was especially low in ARDS, despite depressed levels of glutathione being present in all patients. Although iron regulation was dysfunctional in all groups, the depressed antioxidant barrier in ARDS, and to a lesser extent in COVID-19, might induce greater inflammatory responses with consequent anemia.https://www.mdpi.com/2076-3921/10/9/1460acute hypoxiachronic hypoxiahepcidinironerythropoiesisantioxidant barrier |
| spellingShingle | Lorena Duca Sara Ottolenghi Silvia Coppola Rocco Rinaldo Michele Dei Cas Federico Maria Rubino Rita Paroni Michele Samaja Davide Alberto Chiumello Irene Motta Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019 Antioxidants acute hypoxia chronic hypoxia hepcidin iron erythropoiesis antioxidant barrier |
| title | Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019 |
| title_full | Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019 |
| title_fullStr | Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019 |
| title_full_unstemmed | Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019 |
| title_short | Differential Redox State and Iron Regulation in Chronic Obstructive Pulmonary Disease, Acute Respiratory Distress Syndrome and Coronavirus Disease 2019 |
| title_sort | differential redox state and iron regulation in chronic obstructive pulmonary disease acute respiratory distress syndrome and coronavirus disease 2019 |
| topic | acute hypoxia chronic hypoxia hepcidin iron erythropoiesis antioxidant barrier |
| url | https://www.mdpi.com/2076-3921/10/9/1460 |
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