Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer
Abstract Background Spread through air spaces (STAS) is a pattern of invasion recently identified in non‐small cell lung cancer (NSCLC), with a poor prognosis. However, the predictive impact of STAS in stage IB NSCLC is not well understood. This investigation aims to assess the prognostic influence...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.6211 |
| _version_ | 1827867244556713984 |
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| author | Zixuan Chen Xianqiao Wu Tianzheng Fang Zhen Ge Jiayuan Liu Qinglong Wu Lin Zhou Jianfei Shen Chengwei Zhou |
| author_facet | Zixuan Chen Xianqiao Wu Tianzheng Fang Zhen Ge Jiayuan Liu Qinglong Wu Lin Zhou Jianfei Shen Chengwei Zhou |
| author_sort | Zixuan Chen |
| collection | DOAJ |
| description | Abstract Background Spread through air spaces (STAS) is a pattern of invasion recently identified in non‐small cell lung cancer (NSCLC), with a poor prognosis. However, the predictive impact of STAS in stage IB NSCLC is not well understood. This investigation aims to assess the prognostic influence of STAS in stage IB NSCLC. Methods We reviewed 130 resected stage IB NSCLC between 2010 and 2015. Beyond the central tumor edge, lung parenchymal air gaps containing cancer cells were identified as STAS. In order to estimate recurrence‐free survival (RFS) and overall survival (OS), Cox models and Kaplan–Meier techniques were utilized. Logistic regression analysis was employed to define the factors influencing STAS. Results Of 130 patients, 72 (55.4%) had STAS. STAS was a significant prognosticator. Kaplan–Meier method showed that STAS‐positive patients had a significantly lower OS and RFS than STAS‐negative patients (5‐year OS, 66.5% vs. 90.4%, p = 0.02; 5‐year RFS, 59.5% vs. 89.7%, p = 0.004) In a semiquantitative assessment, the RFS and OS were shorter in survival analysis when STAS increased (5‐year RFS, 89.7%, no STAS, 61.8%, low STAS, 57.2%, high STAS, p = 0.013; 5‐year OS, 90.4%, no STAS, 78.3%, low STAS, 57.2%, high STAS, p = 0.002). The association between STAS and poor differentiation, adenocarcinoma, and vascular invasion (p value was <0.001, 0.047, and 0.041, respectively) was statistically significant. Conclusions The STAS is an aggressive pathological feature. RFS and OS could be significantly reduced by STAS, while it also serves as an independent predictor. |
| first_indexed | 2024-03-12T15:15:20Z |
| format | Article |
| id | doaj.art-c4797b6708ba44589ec2a9860c02a326 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-12T15:15:20Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-c4797b6708ba44589ec2a9860c02a3262023-08-11T14:51:17ZengWileyCancer Medicine2045-76342023-07-011214152461525510.1002/cam4.6211Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancerZixuan Chen0Xianqiao Wu1Tianzheng Fang2Zhen Ge3Jiayuan Liu4Qinglong Wu5Lin Zhou6Jianfei Shen7Chengwei Zhou8Thoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaCardiothoracic Surgery Department Taizhou Hospital of Zhejiang Province, Wenzhou Medical University Linhai ChinaThoracic Surgery Department The First Affiliated Hospital of Ningbo University Ningbo ChinaAbstract Background Spread through air spaces (STAS) is a pattern of invasion recently identified in non‐small cell lung cancer (NSCLC), with a poor prognosis. However, the predictive impact of STAS in stage IB NSCLC is not well understood. This investigation aims to assess the prognostic influence of STAS in stage IB NSCLC. Methods We reviewed 130 resected stage IB NSCLC between 2010 and 2015. Beyond the central tumor edge, lung parenchymal air gaps containing cancer cells were identified as STAS. In order to estimate recurrence‐free survival (RFS) and overall survival (OS), Cox models and Kaplan–Meier techniques were utilized. Logistic regression analysis was employed to define the factors influencing STAS. Results Of 130 patients, 72 (55.4%) had STAS. STAS was a significant prognosticator. Kaplan–Meier method showed that STAS‐positive patients had a significantly lower OS and RFS than STAS‐negative patients (5‐year OS, 66.5% vs. 90.4%, p = 0.02; 5‐year RFS, 59.5% vs. 89.7%, p = 0.004) In a semiquantitative assessment, the RFS and OS were shorter in survival analysis when STAS increased (5‐year RFS, 89.7%, no STAS, 61.8%, low STAS, 57.2%, high STAS, p = 0.013; 5‐year OS, 90.4%, no STAS, 78.3%, low STAS, 57.2%, high STAS, p = 0.002). The association between STAS and poor differentiation, adenocarcinoma, and vascular invasion (p value was <0.001, 0.047, and 0.041, respectively) was statistically significant. Conclusions The STAS is an aggressive pathological feature. RFS and OS could be significantly reduced by STAS, while it also serves as an independent predictor.https://doi.org/10.1002/cam4.6211IB stage non‐small cell lung canceroverall survivalrecurrence‐free survivalspread through air spaces |
| spellingShingle | Zixuan Chen Xianqiao Wu Tianzheng Fang Zhen Ge Jiayuan Liu Qinglong Wu Lin Zhou Jianfei Shen Chengwei Zhou Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer Cancer Medicine IB stage non‐small cell lung cancer overall survival recurrence‐free survival spread through air spaces |
| title | Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer |
| title_full | Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer |
| title_fullStr | Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer |
| title_full_unstemmed | Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer |
| title_short | Prognostic impact of tumor spread through air spaces for T2aN0 stage IB non‐small cell lung cancer |
| title_sort | prognostic impact of tumor spread through air spaces for t2an0 stage ib non small cell lung cancer |
| topic | IB stage non‐small cell lung cancer overall survival recurrence‐free survival spread through air spaces |
| url | https://doi.org/10.1002/cam4.6211 |
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