Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment
Image-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated trea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2021.1970245 |
| _version_ | 1818278672449142784 |
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| author | Yuan-Mao Lin Reto Bale Kristy K. Brock Bruno C. Odisio |
| author_facet | Yuan-Mao Lin Reto Bale Kristy K. Brock Bruno C. Odisio |
| author_sort | Yuan-Mao Lin |
| collection | DOAJ |
| description | Image-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent application of computer-assisted ablation planning, guidance, and intra-procedural response assessment has improved percutaneous ablation outcomes. In addition, the evolving understanding of tumor molecular profiling has brought to light several biological factors associated with oncological outcomes following local therapies. The standardization of ablation procedures, the understanding of previously unknown biological factors affecting ablation outcomes, and the evidence by ongoing prospective clinical trials are poised to change the current perspective and indications on the use of ablation for CLM. |
| first_indexed | 2024-12-12T23:21:09Z |
| format | Article |
| id | doaj.art-c47c2a4f57564800be92b93ad37b8d01 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-12T23:21:09Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-c47c2a4f57564800be92b93ad37b8d012022-12-22T00:08:17ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572022-12-0139164966310.1080/02656736.2021.1970245Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatmentYuan-Mao Lin0Reto Bale1Kristy K. Brock2Bruno C. Odisio3Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAInterventional Oncology-Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Innsbruck, AustriaDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAImage-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent application of computer-assisted ablation planning, guidance, and intra-procedural response assessment has improved percutaneous ablation outcomes. In addition, the evolving understanding of tumor molecular profiling has brought to light several biological factors associated with oncological outcomes following local therapies. The standardization of ablation procedures, the understanding of previously unknown biological factors affecting ablation outcomes, and the evidence by ongoing prospective clinical trials are poised to change the current perspective and indications on the use of ablation for CLM.https://www.tandfonline.com/doi/10.1080/02656736.2021.1970245Colorectal cancerliver metastasespercutaneous ablationliver resection |
| spellingShingle | Yuan-Mao Lin Reto Bale Kristy K. Brock Bruno C. Odisio Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment International Journal of Hyperthermia Colorectal cancer liver metastases percutaneous ablation liver resection |
| title | Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment |
| title_full | Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment |
| title_fullStr | Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment |
| title_full_unstemmed | Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment |
| title_short | Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment |
| title_sort | contemporary evidence on colorectal liver metastases ablation toward a paradigm shift in locoregional treatment |
| topic | Colorectal cancer liver metastases percutaneous ablation liver resection |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2021.1970245 |
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