Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways
Hearing loss is one of the most prevalent sensory disabilities worldwide with huge social and economic burdens. The leading cause of sensorineural hearing loss (SNHL) in children is congenital cytomegalovirus (CMV) infection. Though the implementation of universal screening and early intervention su...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/4/623 |
| _version_ | 1797538705366319104 |
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| author | Sheng-Nan Huang Yue-Peng Zhou Xuan Jiang Bo Yang Han Cheng Min-Hua Luo |
| author_facet | Sheng-Nan Huang Yue-Peng Zhou Xuan Jiang Bo Yang Han Cheng Min-Hua Luo |
| author_sort | Sheng-Nan Huang |
| collection | DOAJ |
| description | Hearing loss is one of the most prevalent sensory disabilities worldwide with huge social and economic burdens. The leading cause of sensorineural hearing loss (SNHL) in children is congenital cytomegalovirus (CMV) infection. Though the implementation of universal screening and early intervention such as antiviral or anti-inflammatory ameliorate the severity of CMV-associated diseases, direct and targeted therapeutics is still seriously lacking. The major hurdle for it is that the mechanism of CMV induced SNHL has not yet been well understood. In this review, we focus on the impact of CMV infection on the key players in inner ear development including the Wnt and Notch signaling pathways. Investigations on these interactions may gain new insights into viral pathogenesis and reveal novel targets for therapy. |
| first_indexed | 2024-03-10T12:35:11Z |
| format | Article |
| id | doaj.art-c47d1a69a99e4aee97d7cae6b6ee6e0c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:35:11Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c47d1a69a99e4aee97d7cae6b6ee6e0c2023-11-21T14:20:40ZengMDPI AGViruses1999-49152021-04-0113462310.3390/v13040623Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling PathwaysSheng-Nan Huang0Yue-Peng Zhou1Xuan Jiang2Bo Yang3Han Cheng4Min-Hua Luo5State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology Wuhan Institute of Virology, Wuhan 430071, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology Wuhan Institute of Virology, Wuhan 430071, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology Wuhan Institute of Virology, Wuhan 430071, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology Wuhan Institute of Virology, Wuhan 430071, ChinaShanghai Public Health Clinical Center, Fudan University, Shanghai 201508, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology Wuhan Institute of Virology, Wuhan 430071, ChinaHearing loss is one of the most prevalent sensory disabilities worldwide with huge social and economic burdens. The leading cause of sensorineural hearing loss (SNHL) in children is congenital cytomegalovirus (CMV) infection. Though the implementation of universal screening and early intervention such as antiviral or anti-inflammatory ameliorate the severity of CMV-associated diseases, direct and targeted therapeutics is still seriously lacking. The major hurdle for it is that the mechanism of CMV induced SNHL has not yet been well understood. In this review, we focus on the impact of CMV infection on the key players in inner ear development including the Wnt and Notch signaling pathways. Investigations on these interactions may gain new insights into viral pathogenesis and reveal novel targets for therapy.https://www.mdpi.com/1999-4915/13/4/623cytomegaloviruscongenital cytomegalovirus infectionsensorineural hearing lossinner ear developmentWnt signaling pathwayNotch signaling pathway |
| spellingShingle | Sheng-Nan Huang Yue-Peng Zhou Xuan Jiang Bo Yang Han Cheng Min-Hua Luo Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways Viruses cytomegalovirus congenital cytomegalovirus infection sensorineural hearing loss inner ear development Wnt signaling pathway Notch signaling pathway |
| title | Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways |
| title_full | Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways |
| title_fullStr | Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways |
| title_full_unstemmed | Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways |
| title_short | Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways |
| title_sort | hearing loss caused by hcmv infection through regulating the wnt and notch signaling pathways |
| topic | cytomegalovirus congenital cytomegalovirus infection sensorineural hearing loss inner ear development Wnt signaling pathway Notch signaling pathway |
| url | https://www.mdpi.com/1999-4915/13/4/623 |
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