Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication.

Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication.

The enormous sequence diversity of HIV remains a major roadblock to the development of a prophylactic vaccine and new approaches to induce protective immunity are needed. Endogenous retrotransposable elements (ERE) such as endogenous retrovirus K (ERV)-K and long interspersed nuclear element-1 (LINE...

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Bibliographic Details
Main Authors: Neil C Sheppard, R Brad Jones, Benjamin J Burwitz, Francesca A Nimityongskul, Laura P Newman, Matthew B Buechler, Jason S Reed, Shari M Piaskowski, Kim L Weisgrau, Philip A Castrovinci, Nancy A Wilson, Mario A Ostrowski, Byung Park, Douglas F Nixon, Eva G Rakasz, Jonah B Sacha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961289?pdf=render

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