Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression
Discovering neural correlates of subjective perception and dissociating them from sensory input has fascinated neuroscientists for a long time. Bistable and multistable perception phenomena have exhibited great experimental potential to address this question. Here, we performed electrophysiological...
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| Format: | Article |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Systems Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnsys.2019.00009/full |
| _version_ | 1818570652420931584 |
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| author | Hamed Bahmani Hamed Bahmani Qinglin Li Qinglin Li Nikos K. Logothetis Nikos K. Logothetis Georgios A. Keliris Georgios A. Keliris Georgios A. Keliris |
| author_facet | Hamed Bahmani Hamed Bahmani Qinglin Li Qinglin Li Nikos K. Logothetis Nikos K. Logothetis Georgios A. Keliris Georgios A. Keliris Georgios A. Keliris |
| author_sort | Hamed Bahmani |
| collection | DOAJ |
| description | Discovering neural correlates of subjective perception and dissociating them from sensory input has fascinated neuroscientists for a long time. Bistable and multistable perception phenomena have exhibited great experimental potential to address this question. Here, we performed electrophysiological recordings from single neurons in lateral intraparietal area (LIP) of rhesus macaques during stimulus and perceptual transitions induced by binocular flash suppression (BFS). LIP neurons demonstrated transient bursts of activity after stimulus presentation and stimulus or perceptual switches but only a minority of cells demonstrated stimulus and perceptual selectivity. To enhance LIP neural selectivity, we performed a second experiment in which the competing stimuli were associated with asymmetric rewards. We found that transient and sustained activities substantially increased while the proportion of stimulus selective neurons remained approximately the same, albeit with increased selectivity magnitude. In addition, we observed mild increases in the proportion of perceptually selective neurons which also showed increase magnitude of selectivity. Importantly, the increased selectivity of cells after the reward manipulation was not directly reflecting the reward size per se but an enhancement in stimulus differentiation. Based on our results, we conjecture that LIP contributes to perceptual transitions and serves a modulatory role in perceptual selection taking into account the stimulus behavioral value. |
| first_indexed | 2024-12-14T13:44:46Z |
| format | Article |
| id | doaj.art-c47de37a8aec429291c99c4e09d9f8b4 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-14T13:44:46Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-c47de37a8aec429291c99c4e09d9f8b42022-12-21T22:59:21ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372019-03-011310.3389/fnsys.2019.00009395360Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash SuppressionHamed Bahmani0Hamed Bahmani1Qinglin Li2Qinglin Li3Nikos K. Logothetis4Nikos K. Logothetis5Georgios A. Keliris6Georgios A. Keliris7Georgios A. Keliris8Department of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, GermanyBernstein Center for Computational Neuroscience, Tuebingen, GermanyDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, GermanyBernstein Center for Computational Neuroscience, Tuebingen, GermanyDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, GermanyDivision of Imaging Science and Biomedical Engineering, University of Manchester, Manchester, United KingdomDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tuebingen, GermanyBernstein Center for Computational Neuroscience, Tuebingen, GermanyBio-Imaging Lab, Department of Biomedical Sciences, University of Antwerp, Wilrijk, BelgiumDiscovering neural correlates of subjective perception and dissociating them from sensory input has fascinated neuroscientists for a long time. Bistable and multistable perception phenomena have exhibited great experimental potential to address this question. Here, we performed electrophysiological recordings from single neurons in lateral intraparietal area (LIP) of rhesus macaques during stimulus and perceptual transitions induced by binocular flash suppression (BFS). LIP neurons demonstrated transient bursts of activity after stimulus presentation and stimulus or perceptual switches but only a minority of cells demonstrated stimulus and perceptual selectivity. To enhance LIP neural selectivity, we performed a second experiment in which the competing stimuli were associated with asymmetric rewards. We found that transient and sustained activities substantially increased while the proportion of stimulus selective neurons remained approximately the same, albeit with increased selectivity magnitude. In addition, we observed mild increases in the proportion of perceptually selective neurons which also showed increase magnitude of selectivity. Importantly, the increased selectivity of cells after the reward manipulation was not directly reflecting the reward size per se but an enhancement in stimulus differentiation. Based on our results, we conjecture that LIP contributes to perceptual transitions and serves a modulatory role in perceptual selection taking into account the stimulus behavioral value.https://www.frontiersin.org/article/10.3389/fnsys.2019.00009/fullLIPBFSrewardelectrophysiologyvisual perceptionparietal cortex |
| spellingShingle | Hamed Bahmani Hamed Bahmani Qinglin Li Qinglin Li Nikos K. Logothetis Nikos K. Logothetis Georgios A. Keliris Georgios A. Keliris Georgios A. Keliris Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression Frontiers in Systems Neuroscience LIP BFS reward electrophysiology visual perception parietal cortex |
| title | Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression |
| title_full | Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression |
| title_fullStr | Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression |
| title_full_unstemmed | Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression |
| title_short | Responses of Neurons in Lateral Intraparietal Area Depend on Stimulus-Associated Reward During Binocular Flash Suppression |
| title_sort | responses of neurons in lateral intraparietal area depend on stimulus associated reward during binocular flash suppression |
| topic | LIP BFS reward electrophysiology visual perception parietal cortex |
| url | https://www.frontiersin.org/article/10.3389/fnsys.2019.00009/full |
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