Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm
Background: Percutaneous ethanol injection has been successfully used for hepatocelular carcinomas (HCC) smaller than 5 cm in size. For larger lesions large volume ethanol injection has not been well explored. Aim: Evaluate the results of intraoperative Ultrasonographic-guided large volume ethanol i...
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| Format: | Article |
| Language: | English |
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Elsevier
2005-07-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119320666 |
| _version_ | 1819108164095705088 |
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| author | Ricardo Mondragón-Sánchez Ana Lilia Garduño-López Elvira Gómez-Gómez Mauricio Frias-Mendivil Alejandro Mondragón-Sánchez Rigoberto Bernal-Maldonado |
| author_facet | Ricardo Mondragón-Sánchez Ana Lilia Garduño-López Elvira Gómez-Gómez Mauricio Frias-Mendivil Alejandro Mondragón-Sánchez Rigoberto Bernal-Maldonado |
| author_sort | Ricardo Mondragón-Sánchez |
| collection | DOAJ |
| description | Background: Percutaneous ethanol injection has been successfully used for hepatocelular carcinomas (HCC) smaller than 5 cm in size. For larger lesions large volume ethanol injection has not been well explored. Aim: Evaluate the results of intraoperative Ultrasonographic-guided large volume ethanol injection for HCC larger than 4 cm in size. Patients and methods: Ten patients were candidates for this treatment between June 1999 and July 2003. A retrospective review of the clinical files was performed. Absolute ethanol, average of 100 mL (range 80-120 mL) was administered intraoperatively. Follow-up evaluation included alpha-fetoprotein (AFP) and ultrasound or computed tomography. Results: There were six women and four men, the median age was 62 years (range 56-80). The median lesion size was 8 cm (range 4-15 cm). Hepatitis C liver cirrhosis was the most common associated chronic liver disease (70%). A significant reduction of AFP levels after treatment was observed (Initial 966 ng/dL, post treatment levels: 42 ng/dL) US and CT scan showed tumor necrosis. Morbidity was 40%. No operative mortality was recorded. The one and four year survival rate was 60% and 20%. Conclusion: Intraoperative US-guided large volume ethanol injection is a safe palliative therapy for cirrhotic patients with HCC lesions greater than 5 cm in size. The impact on survival should be compared in a controlled double blind study. |
| first_indexed | 2024-12-22T03:05:34Z |
| format | Article |
| id | doaj.art-c47f487181174e4ab1969595c0ea9cc6 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-22T03:05:34Z |
| publishDate | 2005-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-c47f487181174e4ab1969595c0ea9cc62022-12-21T18:41:04ZengElsevierAnnals of Hepatology1665-26812005-07-0143200203Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cmRicardo Mondragón-Sánchez0Ana Lilia Garduño-López1Elvira Gómez-Gómez2Mauricio Frias-Mendivil3Alejandro Mondragón-Sánchez4Rigoberto Bernal-Maldonado5Departments of Gastroenterology; Instituto Nacional de Cancerología, Mexico City. Division of Surgery. Centro Médico ISSEMyM, Metepec, México; Address for correspondence:Departments of GastroenterologyDepartments of GastroenterologyDepartments of EpidemiologyInstituto Nacional de Cancerología, Mexico City. Division of Surgery. Centro Médico ISSEMyM, Metepec, MéxicoDepartments of GastroenterologyBackground: Percutaneous ethanol injection has been successfully used for hepatocelular carcinomas (HCC) smaller than 5 cm in size. For larger lesions large volume ethanol injection has not been well explored. Aim: Evaluate the results of intraoperative Ultrasonographic-guided large volume ethanol injection for HCC larger than 4 cm in size. Patients and methods: Ten patients were candidates for this treatment between June 1999 and July 2003. A retrospective review of the clinical files was performed. Absolute ethanol, average of 100 mL (range 80-120 mL) was administered intraoperatively. Follow-up evaluation included alpha-fetoprotein (AFP) and ultrasound or computed tomography. Results: There were six women and four men, the median age was 62 years (range 56-80). The median lesion size was 8 cm (range 4-15 cm). Hepatitis C liver cirrhosis was the most common associated chronic liver disease (70%). A significant reduction of AFP levels after treatment was observed (Initial 966 ng/dL, post treatment levels: 42 ng/dL) US and CT scan showed tumor necrosis. Morbidity was 40%. No operative mortality was recorded. The one and four year survival rate was 60% and 20%. Conclusion: Intraoperative US-guided large volume ethanol injection is a safe palliative therapy for cirrhotic patients with HCC lesions greater than 5 cm in size. The impact on survival should be compared in a controlled double blind study.http://www.sciencedirect.com/science/article/pii/S1665268119320666Large hepatocellular carcinomapercutaneous ethanol injectionnonresectional therapies |
| spellingShingle | Ricardo Mondragón-Sánchez Ana Lilia Garduño-López Elvira Gómez-Gómez Mauricio Frias-Mendivil Alejandro Mondragón-Sánchez Rigoberto Bernal-Maldonado Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm Annals of Hepatology Large hepatocellular carcinoma percutaneous ethanol injection nonresectional therapies |
| title | Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm |
| title_full | Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm |
| title_fullStr | Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm |
| title_full_unstemmed | Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm |
| title_short | Intraoperative US-guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm |
| title_sort | intraoperative us guided large volume ethanol injection for hepatocellular carcinoma greater than 4 cm |
| topic | Large hepatocellular carcinoma percutaneous ethanol injection nonresectional therapies |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119320666 |
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