Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study
AbstractBackground This study aimed to investigate the association between different metabolic syndrome-body mass index (MetS-BMI) phenotypes and the risk of kidney stones.Materials and Methods Participants aged 20–80 years from six consecutive cycles of the NHANES 2007–2018 were included in this st...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | The Aging Male |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13685538.2023.2195932 |
| _version_ | 1797434769553752064 |
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| author | Zhenyang Ye Changjing Wu Yang Xiong Fuxun Zhang Jinyang Luo Lijing Xu Jia Wang Yunjin Bai |
| author_facet | Zhenyang Ye Changjing Wu Yang Xiong Fuxun Zhang Jinyang Luo Lijing Xu Jia Wang Yunjin Bai |
| author_sort | Zhenyang Ye |
| collection | DOAJ |
| description | AbstractBackground This study aimed to investigate the association between different metabolic syndrome-body mass index (MetS-BMI) phenotypes and the risk of kidney stones.Materials and Methods Participants aged 20–80 years from six consecutive cycles of the NHANES 2007–2018 were included in this study. According to their MetS status and BMI, the included participants were allocated into six mutually exclusive groups: metabolically healthy normal weight (MHN)/overweight (MHOW)/obesity (MHO) and metabolically unhealthy normal weight (MUN)/overweight (MUOW)/obesity (MUO). To explore the association between MetS-BMI phenotypes and the risk of kidney stones, binary logistic regression was used to determine the odds ratios (ORs).Results A total of 13,589 participants were included. It was revealed that all the phenotypes with obesity displayed higher risks of kidney stones (OR = 1.38, p < 0.01 for MHO & OR = 1.80, p < 0.001 for MUO, in the fully adjusted model). The risk increased significantly when metabolic dysfunction coexisted with overweight and obesity (OR = 1.39, p < 0.05 for MUOW & OR = 1.80, p < 0.001 for MUO, in the fully adjusted model). Of note, the ORs for the MUO and MUOW groups were higher than those for the MHO and MHOW groups, respectively.Conclusions Obesity and unhealthy metabolic status can jointly increase the risk of kidney stones. Assessing the metabolic status of all individuals may be beneficial for preventing kidney stones. |
| first_indexed | 2024-03-09T10:38:01Z |
| format | Article |
| id | doaj.art-c4815653b7be4a93926ac8d17de02544 |
| institution | Directory Open Access Journal |
| issn | 1368-5538 1473-0790 |
| language | English |
| last_indexed | 2024-03-09T10:38:01Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | The Aging Male |
| spelling | doaj.art-c4815653b7be4a93926ac8d17de025442023-12-01T20:52:03ZengTaylor & Francis GroupThe Aging Male1368-55381473-07902023-12-0126110.1080/13685538.2023.2195932Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional studyZhenyang Ye0Changjing Wu1Yang Xiong2Fuxun Zhang3Jinyang Luo4Lijing Xu5Jia Wang6Yunjin Bai7Department of Urology, West China Xiamen Hospital of Sichuan University, Xiamen, P.R. ChinaAndrology Laboratory, West China Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Urology, West China Xiamen Hospital of Sichuan University, Xiamen, P.R. ChinaDepartment of Urology, West China Xiamen Hospital of Sichuan University, Xiamen, P.R. ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, P.R. ChinaDepartment of Urology, West China Hospital, Sichuan University, Chengdu, P.R. ChinaAbstractBackground This study aimed to investigate the association between different metabolic syndrome-body mass index (MetS-BMI) phenotypes and the risk of kidney stones.Materials and Methods Participants aged 20–80 years from six consecutive cycles of the NHANES 2007–2018 were included in this study. According to their MetS status and BMI, the included participants were allocated into six mutually exclusive groups: metabolically healthy normal weight (MHN)/overweight (MHOW)/obesity (MHO) and metabolically unhealthy normal weight (MUN)/overweight (MUOW)/obesity (MUO). To explore the association between MetS-BMI phenotypes and the risk of kidney stones, binary logistic regression was used to determine the odds ratios (ORs).Results A total of 13,589 participants were included. It was revealed that all the phenotypes with obesity displayed higher risks of kidney stones (OR = 1.38, p < 0.01 for MHO & OR = 1.80, p < 0.001 for MUO, in the fully adjusted model). The risk increased significantly when metabolic dysfunction coexisted with overweight and obesity (OR = 1.39, p < 0.05 for MUOW & OR = 1.80, p < 0.001 for MUO, in the fully adjusted model). Of note, the ORs for the MUO and MUOW groups were higher than those for the MHO and MHOW groups, respectively.Conclusions Obesity and unhealthy metabolic status can jointly increase the risk of kidney stones. Assessing the metabolic status of all individuals may be beneficial for preventing kidney stones.https://www.tandfonline.com/doi/10.1080/13685538.2023.2195932Kidney stonesmetabolic syndromeobesityNHANES |
| spellingShingle | Zhenyang Ye Changjing Wu Yang Xiong Fuxun Zhang Jinyang Luo Lijing Xu Jia Wang Yunjin Bai Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study The Aging Male Kidney stones metabolic syndrome obesity NHANES |
| title | Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study |
| title_full | Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study |
| title_fullStr | Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study |
| title_full_unstemmed | Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study |
| title_short | Obesity, metabolic dysfunction, and risk of kidney stone disease: a national cross-sectional study |
| title_sort | obesity metabolic dysfunction and risk of kidney stone disease a national cross sectional study |
| topic | Kidney stones metabolic syndrome obesity NHANES |
| url | https://www.tandfonline.com/doi/10.1080/13685538.2023.2195932 |
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