Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of in vivo vaccination. To obtain evidence of the induction of systemic antitumor immunity following local IRE-med...

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Bibliographic Details
Main Authors: Hester J. Scheffer, Anita G.M. Stam, Bart Geboers, Laurien G.P.H. Vroomen, Alette Ruarus, Beaunelle de Bruijn, M. Petrousjka van den Tol, Geert Kazemier, Martijn R. Meijerink, Tanja D. de Gruijl
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
irreversible electroporation
locally advanced pancreatic cancer
treg
pd-1
t cells
wt1
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1652532

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