Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model.

Enhanced in vivo activity of cefditoren in pre-immunized mice against penicillin-resistant S. pneumoniae (serotypes 6B, 19F and 23F) in a sepsis model.

BACKGROUND: Specific antibodies are likely to be present before S. pneumoniae infection. We explored cefditoren (CDN) total and free values of serum concentrations exceeding the MIC (t>MIC) related to efficacy in a mice sepsis model, and the effect of specific gammaglobulins on in-vitro phagocyto...

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Bibliographic Details
Main Authors: Fabio Cafini, Jose Yuste, Maria-Jose Giménez, David Sevillano, Lorenzo Aguilar, Luis Alou, Elisa Ramos-Sevillano, Martha Torrico, Natalia González, Ernesto García, Pilar Coronel, Jose Prieto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2919394?pdf=render

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