T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study
Purpose: This study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding. Methods: The MRI-knee-scan...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1391 |
| _version_ | 1797488341206171648 |
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| author | Uwe Schütz Thomas Martensen Sebastian Kleiner Jens Dreyhaupt Martin Wegener Hans-Joachim Wilke Meinrad Beer |
| author_facet | Uwe Schütz Thomas Martensen Sebastian Kleiner Jens Dreyhaupt Martin Wegener Hans-Joachim Wilke Meinrad Beer |
| author_sort | Uwe Schütz |
| collection | DOAJ |
| description | Purpose: This study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding. Methods: The MRI-knee-scans (T2*-mapping) of four skiers using a conventional and a spring-loaded ski binding system, alternately, were acquired before and after 1 h/4 h of exposure to alpine skiing. Intrachondral T2* analysis on 60 defined regions of interest in the femorotibial knee joint (FTJ) was conducted. Intra- and interobserver variability and relative changes in the cartilage T2* signal and thickness were calculated. Results: A relevant decrease in the T2* time after 4 h of alpine skiing could be detected at the majority of measurement times. After overnight recovery, the T2* time increased above baseline. Although, the total T2* signal in the superficial cartilage layers was higher than that in the lower ones, no differences between the layers in the T2* changes could be detected. The central and posterior cartilage zones of the FTJ responded with a stronger T2* alteration than the anterior zones. Conclusions: For the first time, a quantitative MRI study setting could be established to detect early knee cartilage reaction due to alpine skiing. Relevant changes in the T2* time and thus in the intrachondral collagen microstructure and the free water content were observed. |
| first_indexed | 2024-03-10T00:00:43Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:00:43Z |
| publishDate | 2022-06-01 |
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| series | Diagnostics |
| spelling | doaj.art-c484288955cc4cc3923deada21c5b3b22023-11-23T16:17:23ZengMDPI AGDiagnostics2075-44182022-06-01126139110.3390/diagnostics12061391T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility StudyUwe Schütz0Thomas Martensen1Sebastian Kleiner2Jens Dreyhaupt3Martin Wegener4Hans-Joachim Wilke5Meinrad Beer6Department of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, GermanyDepartment of Nuclear Medicine, Technical University Munich, Klinikum Rechts der Isar, 81675 München, GermanyDepartment of Biometrics, University Hospital Ulm, 89081 Ulm, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, GermanyTrauma Research Centre, Institute of Orthopaedic Research and Biomechanics, Ulm University, 89081 Ulm, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Ulm, 89081 Ulm, GermanyPurpose: This study intends to establish a study protocol for the quantitative magnetic resonance imaging (qMRI) measurement of biochemical changes in knee cartilage induced by mechanical stress during alpine skiing with the implementation of new spring-loaded ski binding. Methods: The MRI-knee-scans (T2*-mapping) of four skiers using a conventional and a spring-loaded ski binding system, alternately, were acquired before and after 1 h/4 h of exposure to alpine skiing. Intrachondral T2* analysis on 60 defined regions of interest in the femorotibial knee joint (FTJ) was conducted. Intra- and interobserver variability and relative changes in the cartilage T2* signal and thickness were calculated. Results: A relevant decrease in the T2* time after 4 h of alpine skiing could be detected at the majority of measurement times. After overnight recovery, the T2* time increased above baseline. Although, the total T2* signal in the superficial cartilage layers was higher than that in the lower ones, no differences between the layers in the T2* changes could be detected. The central and posterior cartilage zones of the FTJ responded with a stronger T2* alteration than the anterior zones. Conclusions: For the first time, a quantitative MRI study setting could be established to detect early knee cartilage reaction due to alpine skiing. Relevant changes in the T2* time and thus in the intrachondral collagen microstructure and the free water content were observed.https://www.mdpi.com/2075-4418/12/6/1391T2-mappingcartilageosteoarthritiskneeskiMRI |
| spellingShingle | Uwe Schütz Thomas Martensen Sebastian Kleiner Jens Dreyhaupt Martin Wegener Hans-Joachim Wilke Meinrad Beer T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study Diagnostics T2-mapping cartilage osteoarthritis knee ski MRI |
| title | T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study |
| title_full | T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study |
| title_fullStr | T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study |
| title_full_unstemmed | T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study |
| title_short | T2*-Mapping of Knee Cartilage in Response to Mechanical Loading in Alpine Skiing: A Feasibility Study |
| title_sort | t2 mapping of knee cartilage in response to mechanical loading in alpine skiing a feasibility study |
| topic | T2-mapping cartilage osteoarthritis knee ski MRI |
| url | https://www.mdpi.com/2075-4418/12/6/1391 |
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