Cartilage tissue engineering for craniofacial reconstruction
Severe cartilage defects and congenital anomalies affect millions of people and involve considerable medical expenses. Tissue engineering offers many advantages over conventional treatments, as therapy can be tailored to specific defects using abundant bioengineered resources. This article introduce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2020-09-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2020.01095 |
| _version_ | 1811264291059269632 |
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| author | Min-Sook Kim Hyung-Kyu Kim Deok-Woo Kim |
| author_facet | Min-Sook Kim Hyung-Kyu Kim Deok-Woo Kim |
| author_sort | Min-Sook Kim |
| collection | DOAJ |
| description | Severe cartilage defects and congenital anomalies affect millions of people and involve considerable medical expenses. Tissue engineering offers many advantages over conventional treatments, as therapy can be tailored to specific defects using abundant bioengineered resources. This article introduces the basic concepts of cartilage tissue engineering and reviews recent progress in the field, with a focus on craniofacial reconstruction and facial aesthetics. The basic concepts of tissue engineering consist of cells, scaffolds, and stimuli. Generally, the cartilage tissue engineering process includes the following steps: harvesting autologous chondrogenic cells, cell expansion, redifferentiation, in vitro incubation with a scaffold, and transfer to patients. Despite the promising prospects of cartilage tissue engineering, problems and challenges still exist due to certain limitations. The limited proliferation of chondrocytes and their tendency to dedifferentiate necessitate further developments in stem cell technology and chondrocyte molecular biology. Progress should be made in designing fully biocompatible scaffolds with a minimal immune response to regenerate tissue effectively. |
| first_indexed | 2024-04-12T20:00:28Z |
| format | Article |
| id | doaj.art-c4846614bbbc4efa9b5393ec2710d4c3 |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-12T20:00:28Z |
| publishDate | 2020-09-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-c4846614bbbc4efa9b5393ec2710d4c32022-12-22T03:18:32ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712020-09-01470539240310.5999/aps.2020.010953764Cartilage tissue engineering for craniofacial reconstructionMin-Sook Kim0Hyung-Kyu Kim1Deok-Woo Kim2Department of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, KoreaDepartment of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, KoreaDepartment of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, Ansan, KoreaSevere cartilage defects and congenital anomalies affect millions of people and involve considerable medical expenses. Tissue engineering offers many advantages over conventional treatments, as therapy can be tailored to specific defects using abundant bioengineered resources. This article introduces the basic concepts of cartilage tissue engineering and reviews recent progress in the field, with a focus on craniofacial reconstruction and facial aesthetics. The basic concepts of tissue engineering consist of cells, scaffolds, and stimuli. Generally, the cartilage tissue engineering process includes the following steps: harvesting autologous chondrogenic cells, cell expansion, redifferentiation, in vitro incubation with a scaffold, and transfer to patients. Despite the promising prospects of cartilage tissue engineering, problems and challenges still exist due to certain limitations. The limited proliferation of chondrocytes and their tendency to dedifferentiate necessitate further developments in stem cell technology and chondrocyte molecular biology. Progress should be made in designing fully biocompatible scaffolds with a minimal immune response to regenerate tissue effectively.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2020.01095keywordscartilagetissueengineeringchondrocytestem cell |
| spellingShingle | Min-Sook Kim Hyung-Kyu Kim Deok-Woo Kim Cartilage tissue engineering for craniofacial reconstruction Archives of Plastic Surgery keywords cartilage tissue engineering chondrocyte stem cell |
| title | Cartilage tissue engineering for craniofacial reconstruction |
| title_full | Cartilage tissue engineering for craniofacial reconstruction |
| title_fullStr | Cartilage tissue engineering for craniofacial reconstruction |
| title_full_unstemmed | Cartilage tissue engineering for craniofacial reconstruction |
| title_short | Cartilage tissue engineering for craniofacial reconstruction |
| title_sort | cartilage tissue engineering for craniofacial reconstruction |
| topic | keywords cartilage tissue engineering chondrocyte stem cell |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2020.01095 |
| work_keys_str_mv | AT minsookkim cartilagetissueengineeringforcraniofacialreconstruction AT hyungkyukim cartilagetissueengineeringforcraniofacialreconstruction AT deokwookim cartilagetissueengineeringforcraniofacialreconstruction |