The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia
Melasma is a common disfiguring condition involving acquired hyperpigmentation especially on the face, for which the pathogenesis is still uncertain, however histopathological studies showed that there is not only hyperpigmentation in the epidermis, but also solar elastosis or photo-aging due to abn...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2020-10-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/dr/article/view/8390 |
| _version_ | 1818146711913103360 |
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| author | Dinda Sarasati Murniastuti Kristiana Etnawati Satiti Retno Pudjiati |
| author_facet | Dinda Sarasati Murniastuti Kristiana Etnawati Satiti Retno Pudjiati |
| author_sort | Dinda Sarasati Murniastuti |
| collection | DOAJ |
| description | Melasma is a common disfiguring condition involving acquired hyperpigmentation especially on the face, for which the pathogenesis is still uncertain, however histopathological studies showed that there is not only hyperpigmentation in the epidermis, but also solar elastosis or photo-aging due to abnormality of dermal extracellular matrix which contributes to clinical wrinkles. This study aimed to examine a link between the severity of melasma and facial wrinkles as a manifestation of photoaging in a tropical area. This study was an observational study with crosssectional design, conducted in Yogyakarta, Indonesia involving 51 patients with melasma aged 30-50 years who had fulfilled the inclusion and exclusion criteria. The melasma severity was measured clinically with the modified Melasma Severity Index (mMASI), and objectively with the Melanin Index (MI) and Erythema Index (EI) assessed with Mexameter Courage Khazaka. The wrinkle severity was measured clinically by scoring from forehead horizontal lines, crow’s feet, glabellar and nasolabial lines, and total scores were obtained from all of them. The correlation analysis was done statistically with Spearman’s rank tests. The results showed a weak positive but not significant correlation between the mMASI score and total facial wrinkle score (r: 0.165), and a weak positive non-significant correlation between EI and total facial wrinkle score (r: 0.06). There were significant positive moderate correlations between MI and total facial wrinkle score (r: 0.441), due to significant positive moderate correlations between MI and glabella wrinkle (r: 0.392), and between MI and nasolabial wrinkle (r: 0.339). In conclusion, a positive moderate correlation was found between MI and total facial wrinkle score, especially relating to glabellar and nasolabial wrinkles. However, there was no correlation between mMASI score and total facial wrinkle score. |
| first_indexed | 2024-12-11T12:23:42Z |
| format | Article |
| id | doaj.art-c48499d8849543e783a40ba7515b76f8 |
| institution | Directory Open Access Journal |
| issn | 2036-7392 2036-7406 |
| language | English |
| last_indexed | 2024-12-11T12:23:42Z |
| publishDate | 2020-10-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj.art-c48499d8849543e783a40ba7515b76f82022-12-22T01:07:28ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062020-10-0112210.4081/dr.2020.8390The correlation between severity of melasma with facial wrinkles in Yogyakarta, IndonesiaDinda Sarasati Murniastuti0Kristiana Etnawati1Satiti Retno Pudjiati2Deramatology and Venereology, Department, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, YogyakartaDeramatology and Venereology, Department, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, YogyakartaDeramatology and Venereology, Department, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, YogyakartaMelasma is a common disfiguring condition involving acquired hyperpigmentation especially on the face, for which the pathogenesis is still uncertain, however histopathological studies showed that there is not only hyperpigmentation in the epidermis, but also solar elastosis or photo-aging due to abnormality of dermal extracellular matrix which contributes to clinical wrinkles. This study aimed to examine a link between the severity of melasma and facial wrinkles as a manifestation of photoaging in a tropical area. This study was an observational study with crosssectional design, conducted in Yogyakarta, Indonesia involving 51 patients with melasma aged 30-50 years who had fulfilled the inclusion and exclusion criteria. The melasma severity was measured clinically with the modified Melasma Severity Index (mMASI), and objectively with the Melanin Index (MI) and Erythema Index (EI) assessed with Mexameter Courage Khazaka. The wrinkle severity was measured clinically by scoring from forehead horizontal lines, crow’s feet, glabellar and nasolabial lines, and total scores were obtained from all of them. The correlation analysis was done statistically with Spearman’s rank tests. The results showed a weak positive but not significant correlation between the mMASI score and total facial wrinkle score (r: 0.165), and a weak positive non-significant correlation between EI and total facial wrinkle score (r: 0.06). There were significant positive moderate correlations between MI and total facial wrinkle score (r: 0.441), due to significant positive moderate correlations between MI and glabella wrinkle (r: 0.392), and between MI and nasolabial wrinkle (r: 0.339). In conclusion, a positive moderate correlation was found between MI and total facial wrinkle score, especially relating to glabellar and nasolabial wrinkles. However, there was no correlation between mMASI score and total facial wrinkle score.https://www.pagepress.org/journals/index.php/dr/article/view/8390melasmaphotoagingfacial wrinklesmelanin indexerythema index |
| spellingShingle | Dinda Sarasati Murniastuti Kristiana Etnawati Satiti Retno Pudjiati The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia Dermatology Reports melasma photoaging facial wrinkles melanin index erythema index |
| title | The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia |
| title_full | The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia |
| title_fullStr | The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia |
| title_full_unstemmed | The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia |
| title_short | The correlation between severity of melasma with facial wrinkles in Yogyakarta, Indonesia |
| title_sort | correlation between severity of melasma with facial wrinkles in yogyakarta indonesia |
| topic | melasma photoaging facial wrinkles melanin index erythema index |
| url | https://www.pagepress.org/journals/index.php/dr/article/view/8390 |
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