Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers
Objective To investigate the relationship between triglyceride glucose (TyG) index and the total load of cerebral small vessel disease (CSVD) and its different imaging markers. Methods A total of 202 patients with CSVD admitted to The Third Hospital of Hebei Medical University from January 2020 to M...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2023-11-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2783 |
| _version_ | 1797447875031990272 |
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| author | YIN Yuan⁃yuan LUO Wei⁃gang LIU Wan⁃hu BU Wei XU Yu⁃zhu CAO Xiao⁃yun REN Hui⁃ling |
| author_facet | YIN Yuan⁃yuan LUO Wei⁃gang LIU Wan⁃hu BU Wei XU Yu⁃zhu CAO Xiao⁃yun REN Hui⁃ling |
| author_sort | YIN Yuan⁃yuan |
| collection | DOAJ |
| description | Objective To investigate the relationship between triglyceride glucose (TyG) index and the total load of cerebral small vessel disease (CSVD) and its different imaging markers. Methods A total of 202 patients with CSVD admitted to The Third Hospital of Hebei Medical University from January 2020 to May 2022 were selected. The clinical data of all patients were collected and TyG index was calculated. The lacunes, cerebral microbleeds (CMBs), white matter hyperintensity (WMH) and enlarged perivascular space (EPVS) were evaluated by MRI, and total load of CSVD score was calculated. Results 1) TyG index and total load of CSVD score: Logistic regression analysis showed the male (OR = 2.245, 95%CI: 1.017-4.957; P = 0.045), increase of age (OR = 1.084, 95%CI: 1.046-1.124; P = 0.000), hypertension (OR = 2.457, 95%CI: 1.189-5.078; P = 0.015) and increase of TyG index (OR = 2.657, 95%CI: 1.353-5.216; P = 0.005) were risk factors for moderate and severe total load of CSVD. 2) TyG index and imaging markers of CSVD: Logistic regression analysis showed the increase of TyG index was the risk factor of moderate and severe WMH (OR = 2.313, 95%CI: 1.095-4.885; P = 0.028), CMBs (OR = 1.690, 95%CI: 1.011-2.824; P = 0.045), lacunes (OR = 2.087, 95%CI: 1.235-3.525; P = 0.006), moderate and severe EPVS in basal ganglia (OR = 2.005, 95%CI: 1.190-3.378; P = 0.009). Conclusions TyG index is associated with the total load and various imaging markers of CSVD, which can be used as a valuable biomarker to evaluate CSVD and its severity. |
| first_indexed | 2024-03-09T14:02:17Z |
| format | Article |
| id | doaj.art-c484fe85f5f547b588c0292dc63c14d1 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-03-09T14:02:17Z |
| publishDate | 2023-11-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-c484fe85f5f547b588c0292dc63c14d12023-11-30T07:45:12ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312023-11-012311993100010.3969/j.issn.1672⁃6731.2023.11.0072737Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markersYIN Yuan⁃yuan0LUO Wei⁃gang1LIU Wan⁃hu2BU Wei3XU Yu⁃zhu4CAO Xiao⁃yun5REN Hui⁃ling6Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaDepartment of Neurosurgery, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaDepartment of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, ChinaObjective To investigate the relationship between triglyceride glucose (TyG) index and the total load of cerebral small vessel disease (CSVD) and its different imaging markers. Methods A total of 202 patients with CSVD admitted to The Third Hospital of Hebei Medical University from January 2020 to May 2022 were selected. The clinical data of all patients were collected and TyG index was calculated. The lacunes, cerebral microbleeds (CMBs), white matter hyperintensity (WMH) and enlarged perivascular space (EPVS) were evaluated by MRI, and total load of CSVD score was calculated. Results 1) TyG index and total load of CSVD score: Logistic regression analysis showed the male (OR = 2.245, 95%CI: 1.017-4.957; P = 0.045), increase of age (OR = 1.084, 95%CI: 1.046-1.124; P = 0.000), hypertension (OR = 2.457, 95%CI: 1.189-5.078; P = 0.015) and increase of TyG index (OR = 2.657, 95%CI: 1.353-5.216; P = 0.005) were risk factors for moderate and severe total load of CSVD. 2) TyG index and imaging markers of CSVD: Logistic regression analysis showed the increase of TyG index was the risk factor of moderate and severe WMH (OR = 2.313, 95%CI: 1.095-4.885; P = 0.028), CMBs (OR = 1.690, 95%CI: 1.011-2.824; P = 0.045), lacunes (OR = 2.087, 95%CI: 1.235-3.525; P = 0.006), moderate and severe EPVS in basal ganglia (OR = 2.005, 95%CI: 1.190-3.378; P = 0.009). Conclusions TyG index is associated with the total load and various imaging markers of CSVD, which can be used as a valuable biomarker to evaluate CSVD and its severity.http://www.cjcnn.org/index.php/cjcnn/article/view/2783cerebral small vessel diseasetriglyceridesglucoseinsulin resistancerisk factorslogistic models |
| spellingShingle | YIN Yuan⁃yuan LUO Wei⁃gang LIU Wan⁃hu BU Wei XU Yu⁃zhu CAO Xiao⁃yun REN Hui⁃ling Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers Chinese Journal of Contemporary Neurology and Neurosurgery cerebral small vessel disease triglycerides glucose insulin resistance risk factors logistic models |
| title | Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers |
| title_full | Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers |
| title_fullStr | Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers |
| title_full_unstemmed | Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers |
| title_short | Study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers |
| title_sort | study on the relationship between triglyceride glucose index and cerebral small vessel disease and its different imaging markers |
| topic | cerebral small vessel disease triglycerides glucose insulin resistance risk factors logistic models |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2783 |
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