Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study
Abstract. Background:. Vaccination has been shown effective in controlling the global coronavirus disease 2019 (COVID-19) pandemic and reducing severe cases. This study was to assess the flare and change in disease activity after COVID-19 vaccination in patients with stable rheumatoid arthritis (RA)...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-10-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000002562 |
| _version_ | 1797646880871546880 |
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| author | Yan Geng Yong Fan Yu Wang Xuerong Deng Lanlan Ji Xiaohui Zhang Zhibo Song Hong Huang Yanni Gui Haoze Zhang Xiaoying Sun Guangtao Li Juan Zhao Zhuoli Zhang Lishao Guo |
| author_facet | Yan Geng Yong Fan Yu Wang Xuerong Deng Lanlan Ji Xiaohui Zhang Zhibo Song Hong Huang Yanni Gui Haoze Zhang Xiaoying Sun Guangtao Li Juan Zhao Zhuoli Zhang Lishao Guo |
| author_sort | Yan Geng |
| collection | DOAJ |
| description | Abstract. Background:. Vaccination has been shown effective in controlling the global coronavirus disease 2019 (COVID-19) pandemic and reducing severe cases. This study was to assess the flare and change in disease activity after COVID-19 vaccination in patients with stable rheumatoid arthritis (RA).
Methods:. A prospective cohort of RA patients in remission or with low disease activity was divided into a vaccination group and a non-vaccination group based on their COVID-19 vaccination status. Each of them was examined every 3 to 6 months. In the vaccination group, disease activity was compared before and after vaccination. The rates of flare defined as disease activity scores based on 28-joint count (DAS28) >3.2 with ΔDAS28 ≥0.6 were compared between vaccination and non-vaccination groups.
Results:. A total of 202 eligible RA patients were enrolled. Of these, 98 patients received no vaccine shot (non-vaccination group), and 104 patients received two doses of vaccine (vaccination group). The median time interval from pre-vaccination visit to the first immunization and from the second dose of vaccine to post-vaccination visit was 67 days and 83 days, respectively. The disease activity scores at pre-vaccination and post-vaccination visits in the vaccination group patients were similar. At enrollment, gender, RA disease course, seropositivity, and disease activity were comparable across the two groups. Flare was observed in five (4.8%) of the vaccination group patients and nine (9.2%) of the non-vaccination group patients at post-vaccination assessment (P = 0.221). In terms of safety, 29 (27.9%) patients experienced adverse events (AEs) after vaccination. No serious AEs occurred.
Conclusions:. COVID-19 vaccinations had no significant effect on disease activity or risk of flare in RA patients in remission or with low disease activity. Patients with stable RA should be encouraged to receive the COVID-19 vaccination. |
| first_indexed | 2024-03-11T15:09:11Z |
| format | Article |
| id | doaj.art-c4856f4fc5ce4f3481fbd2c9f830bb2b |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-03-11T15:09:11Z |
| publishDate | 2023-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-c4856f4fc5ce4f3481fbd2c9f830bb2b2023-10-30T03:37:50ZengWolters KluwerChinese Medical Journal0366-69992542-56412023-10-01136192324232910.1097/CM9.0000000000002562202310050-00006Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort studyYan Geng0Yong Fan1Yu Wang2Xuerong Deng3Lanlan Ji4Xiaohui Zhang5Zhibo Song6Hong Huang7Yanni Gui8Haoze Zhang9Xiaoying Sun10Guangtao Li11Juan Zhao12Zhuoli Zhang13Lishao Guo14Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.Abstract. Background:. Vaccination has been shown effective in controlling the global coronavirus disease 2019 (COVID-19) pandemic and reducing severe cases. This study was to assess the flare and change in disease activity after COVID-19 vaccination in patients with stable rheumatoid arthritis (RA). Methods:. A prospective cohort of RA patients in remission or with low disease activity was divided into a vaccination group and a non-vaccination group based on their COVID-19 vaccination status. Each of them was examined every 3 to 6 months. In the vaccination group, disease activity was compared before and after vaccination. The rates of flare defined as disease activity scores based on 28-joint count (DAS28) >3.2 with ΔDAS28 ≥0.6 were compared between vaccination and non-vaccination groups. Results:. A total of 202 eligible RA patients were enrolled. Of these, 98 patients received no vaccine shot (non-vaccination group), and 104 patients received two doses of vaccine (vaccination group). The median time interval from pre-vaccination visit to the first immunization and from the second dose of vaccine to post-vaccination visit was 67 days and 83 days, respectively. The disease activity scores at pre-vaccination and post-vaccination visits in the vaccination group patients were similar. At enrollment, gender, RA disease course, seropositivity, and disease activity were comparable across the two groups. Flare was observed in five (4.8%) of the vaccination group patients and nine (9.2%) of the non-vaccination group patients at post-vaccination assessment (P = 0.221). In terms of safety, 29 (27.9%) patients experienced adverse events (AEs) after vaccination. No serious AEs occurred. Conclusions:. COVID-19 vaccinations had no significant effect on disease activity or risk of flare in RA patients in remission or with low disease activity. Patients with stable RA should be encouraged to receive the COVID-19 vaccination.http://journals.lww.com/10.1097/CM9.0000000000002562 |
| spellingShingle | Yan Geng Yong Fan Yu Wang Xuerong Deng Lanlan Ji Xiaohui Zhang Zhibo Song Hong Huang Yanni Gui Haoze Zhang Xiaoying Sun Guangtao Li Juan Zhao Zhuoli Zhang Lishao Guo Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study Chinese Medical Journal |
| title | Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study |
| title_full | Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study |
| title_fullStr | Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study |
| title_full_unstemmed | Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study |
| title_short | Flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination: A prospective Chinese cohort study |
| title_sort | flare and change in disease activity among patients with stable rheumatoid arthritis following coronavirus disease 2019 vaccination a prospective chinese cohort study |
| url | http://journals.lww.com/10.1097/CM9.0000000000002562 |
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