An in vivo pharmacokinetic study of metformin microparticles as an oral sustained release formulation in rabbits

An in vivo pharmacokinetic study of metformin microparticles as an oral sustained release formulation in rabbits

Abstract Background Metformin hydrochloride is a biguanide derivative that has been widely used to treat type 2 diabetes in humans. In veterinary medicine, metformin has shown increasing potential for diabetes treatment in different species, such as equids, dogs, cats and rabbits. It is highly hydro...

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Bibliographic Details
Main Authors: Sihem Bouriche, Angela Alonso-García, Carlos M. Cárceles-Rodríguez, Farouk Rezgui, Emilio Fernández-Varón
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Veterinary Research
Subjects:
Metformin
Controlled-release
Microparticles
Pharmacokinetics
Polymeric-based formulations
Online Access:https://doi.org/10.1186/s12917-021-03016-3

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