Experimental and theoretical insights into the effects of pH on catalysis of bond-cleavage by the lignin peroxidase isozyme H8 from Phanerochaete chrysosporium

Experimental and theoretical insights into the effects of pH on catalysis of bond-cleavage by the lignin peroxidase isozyme H8 from Phanerochaete chrysosporium

Abstract Background Lignin peroxidases catalyze a variety of reactions, resulting in cleavage of both β-O-4′ ether bonds and C–C bonds in lignin, both of which are essential for depolymerizing lignin into fragments amendable to biological or chemical upgrading to valuable products. Studies of the sp...

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Bibliographic Details
Main Authors: Le Thanh Mai Pham, Kai Deng, Trent R. Northen, Steven W. Singer, Paul D. Adams, Blake A. Simmons, Kenneth L. Sale
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Biotechnology for Biofuels
Subjects:
Phanerochaete chrysosporium
Lignin peroxidase
Lignin degradation
Ab initio molecular dynamic simulations
Quantum calculation
Online Access:https://doi.org/10.1186/s13068-021-01953-7

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