Vγ9Vδ2 T Cells in the Bone Marrow of Myeloma Patients: A Paradigm of Microenvironment-Induced Immune Suppression

Vγ9Vδ2 T Cells in the Bone Marrow of Myeloma Patients: A Paradigm of Microenvironment-Induced Immune Suppression

Vγ9Vδ2 T cells are non-conventional T cells with a natural inclination to recognize and kill cancer cells. Malignant B cells, including myeloma cells, are privileged targets of Vγ9Vδ2 T cells in vitro. However, this inclination is often lost in vivo due to multiple mechanisms mediated by tumor cells...

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Bibliographic Details
Main Authors: Barbara Castella, Myriam Foglietta, Chiara Riganti, Massimo Massaia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
Vγ9Vδ2 T cells
immune checkpoints
multiple myeloma
immune suppression
bone marrow
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01492/full

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