P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement
Abstract Purpose/Background/Objectives Acute kidney injury (AKI) is a serious postoperative complication. Increased arterial stiffness has been shown to be an independent risk factor for cardiovascular events. Our aim was to investigate whether arterial stiffness is a predictor of AKI in patients fo...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
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| Series: | Artery Research |
| Online Access: | https://doi.org/10.2991/artres.k-191224.166 |
| _version_ | 1797275307997134848 |
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| author | Evangelia Sigala Charalambos Vlachopoulos Konstantinos Triantafyllou Andreas Katsaros Nikolaos Koumallos Vasilios Lozos Nikolaos Baikoussis Ilias Kouerinis Nikolaos Giakis Demosthenous Michael Dimitrios Terentes Printzios Konstantinos Filis Dimitrios Tousoulis |
| author_facet | Evangelia Sigala Charalambos Vlachopoulos Konstantinos Triantafyllou Andreas Katsaros Nikolaos Koumallos Vasilios Lozos Nikolaos Baikoussis Ilias Kouerinis Nikolaos Giakis Demosthenous Michael Dimitrios Terentes Printzios Konstantinos Filis Dimitrios Tousoulis |
| author_sort | Evangelia Sigala |
| collection | DOAJ |
| description | Abstract Purpose/Background/Objectives Acute kidney injury (AKI) is a serious postoperative complication. Increased arterial stiffness has been shown to be an independent risk factor for cardiovascular events. Our aim was to investigate whether arterial stiffness is a predictor of AKI in patients following surgical aortic valve replacement (SAVR). Methods Eighty-four patients (mean age 72 ± 8 years, 34 females) with moderate to severe aortic stenosis undergoing SAVR were included. As indicators of arterial stiffness aortic hemodynamics, carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) were assessed prior to surgery. Renal dysfunction was defined when eGFR was below 60 ml/min (n = 28, 33%). AKI was defined using KDIQO criteria. Results Twelve patients (14%) developed AKI. There was no significant difference in aortic hemodynamics and cfPWV between the two groups. baPWV significantly correlated with AKI (r = 0.313, p = 0.004). In logistic regression analysis, increase of baPWV per 1 Standard Deviation (Odds Ratio [OR] = 2.76, 95% Confidence intervals [CI]: 1.25–6.11, p = 0.012) and presence of renal dysfunction (OR = 14.93, 95% CI: 2.55–87.32, p = 0.003) were associated with higher risk for AKI even after adjustment for age, gender, systolic blood pressure and diabetes. baPWV was a stronger predictor of AKI than baseline creatinine (Area under the curve [AUC] 0.68, 95% CI: 0.52–0.84, p = 0.05 vs AUC 0.61, 95% CI: 0.46–0.77, p = 0.21; p < 0.05). Conclusion baPWV could be considered as a useful predictive biomarker for AKI after SAVR, especially in patients with renal dysfunction prior to surgery. |
| first_indexed | 2024-03-07T15:12:23Z |
| format | Article |
| id | doaj.art-c48789dfb95e400295823962cf6834d0 |
| institution | Directory Open Access Journal |
| issn | 1872-9312 1876-4401 |
| language | English |
| last_indexed | 2024-03-07T15:12:23Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-c48789dfb95e400295823962cf6834d02024-03-05T18:14:22ZengBMCArtery Research1872-93121876-44012020-02-0125S1S182S18210.2991/artres.k-191224.166P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve ReplacementEvangelia Sigala0Charalambos Vlachopoulos1Konstantinos Triantafyllou2Andreas Katsaros3Nikolaos Koumallos4Vasilios Lozos5Nikolaos Baikoussis6Ilias Kouerinis7Nikolaos Giakis8Demosthenous Michael9Dimitrios Terentes Printzios10Konstantinos Filis11Dimitrios Tousoulis12Hippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensHippokration Hospital of AthensAbstract Purpose/Background/Objectives Acute kidney injury (AKI) is a serious postoperative complication. Increased arterial stiffness has been shown to be an independent risk factor for cardiovascular events. Our aim was to investigate whether arterial stiffness is a predictor of AKI in patients following surgical aortic valve replacement (SAVR). Methods Eighty-four patients (mean age 72 ± 8 years, 34 females) with moderate to severe aortic stenosis undergoing SAVR were included. As indicators of arterial stiffness aortic hemodynamics, carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) were assessed prior to surgery. Renal dysfunction was defined when eGFR was below 60 ml/min (n = 28, 33%). AKI was defined using KDIQO criteria. Results Twelve patients (14%) developed AKI. There was no significant difference in aortic hemodynamics and cfPWV between the two groups. baPWV significantly correlated with AKI (r = 0.313, p = 0.004). In logistic regression analysis, increase of baPWV per 1 Standard Deviation (Odds Ratio [OR] = 2.76, 95% Confidence intervals [CI]: 1.25–6.11, p = 0.012) and presence of renal dysfunction (OR = 14.93, 95% CI: 2.55–87.32, p = 0.003) were associated with higher risk for AKI even after adjustment for age, gender, systolic blood pressure and diabetes. baPWV was a stronger predictor of AKI than baseline creatinine (Area under the curve [AUC] 0.68, 95% CI: 0.52–0.84, p = 0.05 vs AUC 0.61, 95% CI: 0.46–0.77, p = 0.21; p < 0.05). Conclusion baPWV could be considered as a useful predictive biomarker for AKI after SAVR, especially in patients with renal dysfunction prior to surgery.https://doi.org/10.2991/artres.k-191224.166 |
| spellingShingle | Evangelia Sigala Charalambos Vlachopoulos Konstantinos Triantafyllou Andreas Katsaros Nikolaos Koumallos Vasilios Lozos Nikolaos Baikoussis Ilias Kouerinis Nikolaos Giakis Demosthenous Michael Dimitrios Terentes Printzios Konstantinos Filis Dimitrios Tousoulis P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement Artery Research |
| title | P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement |
| title_full | P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement |
| title_fullStr | P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement |
| title_full_unstemmed | P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement |
| title_short | P146 The Predictive Role of Arterial Stiffness in the Development of Acute Kidney Injury in Patients Undergoing Surgical Aortic Valve Replacement |
| title_sort | p146 the predictive role of arterial stiffness in the development of acute kidney injury in patients undergoing surgical aortic valve replacement |
| url | https://doi.org/10.2991/artres.k-191224.166 |
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