A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks
Background: The study is aimed to investigate the metabolic alterations and changes in biochemical parameters associated with extended mask. Methods: It was a prospective comparative study conducted on 129 participants comprised of 37 healthy controls and 92 health care workers using different kind...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Lung India |
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| Online Access: | http://www.lungindia.com/article.asp?issn=0970-2113;year=2023;volume=40;issue=2;spage=134;epage=142;aulast=Patel |
| _version_ | 1797775444649443328 |
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| author | Suprava Patel Eli Mohapatra Asha K Suganthy Seema Shah Jessy Abraham Rachita Nanda Ajoy K Behera Ashish Gupta |
| author_facet | Suprava Patel Eli Mohapatra Asha K Suganthy Seema Shah Jessy Abraham Rachita Nanda Ajoy K Behera Ashish Gupta |
| author_sort | Suprava Patel |
| collection | DOAJ |
| description | Background: The study is aimed to investigate the metabolic alterations and changes in biochemical parameters associated with extended mask. Methods: It was a prospective comparative study conducted on 129 participants comprised of 37 healthy controls and 92 health care workers using different kind of masks like, cloth mask, surgical masks and N95-FFR/PPE. Two samples on day-1 and day-10 were collected for analysis of blood gas parameters, serum hypoxia-inducible factor-α (HIF-α), and erythropoietin (EPO). Results: Oxygen saturation percentage (sO2) of 72.68 (P = 0.033) was significantly low, whereas, Na+ (P = 0.05) and Ca2+ (P < 0.001) were raised in exposed individuals than the healthy controls. The serum HIF-α level of 3.26 ng/mL, was considerable higher in the exposed individuals than controls (P = 0.001). pO2 and sO2 were the lowest and HIF-α and EPO were raised in N95-FFR/PPE of all mask users (P < 0.01). A significant difference was evidenced for pCO2, pH, Na+, Ca2+, and EPO in the exposed group. A positive correlation between the duration of mask use (in hours) with HIF-α (r = 0.247, P = 0.005) and Ca2+ (r = 0.306, P < 0.001) was observed. The major complaints in N95-FFR/PPE users were headache (15.2%) and polydipsia (33.3%). Conclusion: The study findings depicted a significant metabolic alterations in PPE/N95 users which could be due to chronic hypoxic exposure of the tissues. |
| first_indexed | 2024-03-12T22:35:50Z |
| format | Article |
| id | doaj.art-c487ee39f45d42859b74677ba7939be4 |
| institution | Directory Open Access Journal |
| issn | 0970-2113 0974-598X |
| language | English |
| last_indexed | 2024-03-12T22:35:50Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Lung India |
| spelling | doaj.art-c487ee39f45d42859b74677ba7939be42023-07-21T12:44:54ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2023-01-0140213414210.4103/lungindia.lungindia_343_22A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masksSuprava PatelEli MohapatraAsha K SuganthySeema ShahJessy AbrahamRachita NandaAjoy K BeheraAshish GuptaBackground: The study is aimed to investigate the metabolic alterations and changes in biochemical parameters associated with extended mask. Methods: It was a prospective comparative study conducted on 129 participants comprised of 37 healthy controls and 92 health care workers using different kind of masks like, cloth mask, surgical masks and N95-FFR/PPE. Two samples on day-1 and day-10 were collected for analysis of blood gas parameters, serum hypoxia-inducible factor-α (HIF-α), and erythropoietin (EPO). Results: Oxygen saturation percentage (sO2) of 72.68 (P = 0.033) was significantly low, whereas, Na+ (P = 0.05) and Ca2+ (P < 0.001) were raised in exposed individuals than the healthy controls. The serum HIF-α level of 3.26 ng/mL, was considerable higher in the exposed individuals than controls (P = 0.001). pO2 and sO2 were the lowest and HIF-α and EPO were raised in N95-FFR/PPE of all mask users (P < 0.01). A significant difference was evidenced for pCO2, pH, Na+, Ca2+, and EPO in the exposed group. A positive correlation between the duration of mask use (in hours) with HIF-α (r = 0.247, P = 0.005) and Ca2+ (r = 0.306, P < 0.001) was observed. The major complaints in N95-FFR/PPE users were headache (15.2%) and polydipsia (33.3%). Conclusion: The study findings depicted a significant metabolic alterations in PPE/N95 users which could be due to chronic hypoxic exposure of the tissues.http://www.lungindia.com/article.asp?issn=0970-2113;year=2023;volume=40;issue=2;spage=134;epage=142;aulast=Patelblood gas parametersclinical symptomserythropoietinhypoxia inducible factorn95-ffrppe |
| spellingShingle | Suprava Patel Eli Mohapatra Asha K Suganthy Seema Shah Jessy Abraham Rachita Nanda Ajoy K Behera Ashish Gupta A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks Lung India blood gas parameters clinical symptoms erythropoietin hypoxia inducible factor n95-ffr ppe |
| title | A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks |
| title_full | A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks |
| title_fullStr | A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks |
| title_full_unstemmed | A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks |
| title_short | A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks |
| title_sort | pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks |
| topic | blood gas parameters clinical symptoms erythropoietin hypoxia inducible factor n95-ffr ppe |
| url | http://www.lungindia.com/article.asp?issn=0970-2113;year=2023;volume=40;issue=2;spage=134;epage=142;aulast=Patel |
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