Detection and a possible link between parvovirus B19 and thyroid cancer
Human parvovirus B19 (B19) is a small, non-enveloped virus and belongs to Parvoviridae family. B19 persists in many tissues such as thyroid tissue and even thyroid cancer. The main aim of this study was to determine the presence of B19, its association with increased inflammation in thyroid tissue,...
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| Format: | Article |
| Language: | English |
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IOS Press
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317703634 |
| _version_ | 1818617680485154816 |
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| author | Ashkan Etemadi Shayan Mostafaei Kheirollah Yari Amir Ghasemi Hamzeh Minaei Chenar Mohsen Moghoofei |
| author_facet | Ashkan Etemadi Shayan Mostafaei Kheirollah Yari Amir Ghasemi Hamzeh Minaei Chenar Mohsen Moghoofei |
| author_sort | Ashkan Etemadi |
| collection | DOAJ |
| description | Human parvovirus B19 (B19) is a small, non-enveloped virus and belongs to Parvoviridae family. B19 persists in many tissues such as thyroid tissue and even thyroid cancer. The main aim of this study was to determine the presence of B19, its association with increased inflammation in thyroid tissue, and thus its possible role in thyroid cancer progression. Studies have shown that virus replication in non-permissive tissue leads to overexpression of non-structural protein and results in upregulation of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha. A total of 36 paraffin-embedded thyroid specimens and serum were collected from patients and 12 samples were used as control. Various methods were employed, including polymerase chain reaction, real-time polymerase chain reaction, and enzyme-linked immunosorbent assay. The results have shown the presence of B19 DNA in 31 of 36 samples (86.11%). Almost in all samples, the levels of non-structural protein 1, nuclear factor kappa B, tumor necrosis factor alpha, and interleukin 6 were simultaneously high. The presence of parvovirus B19 has a significant positive correlation with nuclear factor kappa B, tumor necrosis factor alpha, and interleukin 6 levels. This study suggests that B19 infection may play an important role in tumorigenesis and thyroid cancer development via the inflammatory mechanisms. |
| first_indexed | 2024-12-16T17:09:33Z |
| format | Article |
| id | doaj.art-c487ee925d5d4989a8286bbab3389256 |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-16T17:09:33Z |
| publishDate | 2017-05-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-c487ee925d5d4989a8286bbab33892562022-12-21T22:23:28ZengIOS PressTumor Biology1423-03802017-05-013910.1177/1010428317703634Detection and a possible link between parvovirus B19 and thyroid cancerAshkan Etemadi0Shayan Mostafaei1Kheirollah Yari2Amir Ghasemi3Hamzeh Minaei Chenar4Mohsen Moghoofei5Department of Biology, Faculty of Science, Shahrekord University, Shahrekord, IranDepartment of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranMedical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Materials Science and Engineering, Sharif University of Technology, Tehran, IranDepartment of Agronomy and Plant Breeding, Razi University, Kermanshah, IranStudent Research Committee, Iran University of Medical Sciences, Tehran, IranHuman parvovirus B19 (B19) is a small, non-enveloped virus and belongs to Parvoviridae family. B19 persists in many tissues such as thyroid tissue and even thyroid cancer. The main aim of this study was to determine the presence of B19, its association with increased inflammation in thyroid tissue, and thus its possible role in thyroid cancer progression. Studies have shown that virus replication in non-permissive tissue leads to overexpression of non-structural protein and results in upregulation of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor alpha. A total of 36 paraffin-embedded thyroid specimens and serum were collected from patients and 12 samples were used as control. Various methods were employed, including polymerase chain reaction, real-time polymerase chain reaction, and enzyme-linked immunosorbent assay. The results have shown the presence of B19 DNA in 31 of 36 samples (86.11%). Almost in all samples, the levels of non-structural protein 1, nuclear factor kappa B, tumor necrosis factor alpha, and interleukin 6 were simultaneously high. The presence of parvovirus B19 has a significant positive correlation with nuclear factor kappa B, tumor necrosis factor alpha, and interleukin 6 levels. This study suggests that B19 infection may play an important role in tumorigenesis and thyroid cancer development via the inflammatory mechanisms.https://doi.org/10.1177/1010428317703634 |
| spellingShingle | Ashkan Etemadi Shayan Mostafaei Kheirollah Yari Amir Ghasemi Hamzeh Minaei Chenar Mohsen Moghoofei Detection and a possible link between parvovirus B19 and thyroid cancer Tumor Biology |
| title | Detection and a possible link between parvovirus B19 and thyroid cancer |
| title_full | Detection and a possible link between parvovirus B19 and thyroid cancer |
| title_fullStr | Detection and a possible link between parvovirus B19 and thyroid cancer |
| title_full_unstemmed | Detection and a possible link between parvovirus B19 and thyroid cancer |
| title_short | Detection and a possible link between parvovirus B19 and thyroid cancer |
| title_sort | detection and a possible link between parvovirus b19 and thyroid cancer |
| url | https://doi.org/10.1177/1010428317703634 |
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