No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2
Background: the geographical similarities of the Dutch 2007–2010 Q fever outbreak and the start of the 2020 coronavirus disease 19 (COVID-19) outbreak in the Netherlands raised questions and provided a unique opportunity to study an association between <i>Coxiella burnetii</i> infection...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/526 |
| _version_ | 1797487059038896128 |
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| author | Jesper M. Weehuizen Rik van Spronsen Andy I. M. Hoepelman Chantal P. Bleeker-Rovers Jan Jelrik Oosterheert Peter C. Wever |
| author_facet | Jesper M. Weehuizen Rik van Spronsen Andy I. M. Hoepelman Chantal P. Bleeker-Rovers Jan Jelrik Oosterheert Peter C. Wever |
| author_sort | Jesper M. Weehuizen |
| collection | DOAJ |
| description | Background: the geographical similarities of the Dutch 2007–2010 Q fever outbreak and the start of the 2020 coronavirus disease 19 (COVID-19) outbreak in the Netherlands raised questions and provided a unique opportunity to study an association between <i>Coxiella burnetii</i> infection and the outcome following SARS-CoV-2 infection. Methods: We performed a retrospective cohort study in two Dutch hospitals. We assessed evidence of previous <i>C. burnetii</i> infection in COVID-19 patients diagnosed at the ED during the first COVID-19 wave and compared a combined outcome of in-hospital mortality and intensive care unit (ICU) admission using adjusted odds ratios (OR). Results: In total, 629 patients were included with a mean age of 68.0 years. Evidence of previous <i>C. burnetii</i> infection was found in 117 patients (18.6%). The combined primary outcome occurred in 40.2% and 40.4% of patients with and without evidence of previous <i>C. burnetii</i> infection respectively (adjusted OR of 0.926 (95% CI 0.605–1.416)). The adjusted OR of the secondary outcomes in-hospital mortality, ICU-admission and regular ward admission did not show an association either. Conclusion: no influence of previous <i>C. burnetii</i> infection on the risk of ICU admission and/or mortality for patients with COVID-19 presenting at the ED was observed. |
| first_indexed | 2024-03-09T23:43:12Z |
| format | Article |
| id | doaj.art-c489fc2f77f14b22ae5bdba42989f772 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:43:12Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c489fc2f77f14b22ae5bdba42989f7722023-11-23T16:49:49ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111352610.3390/jcm11030526No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2Jesper M. Weehuizen0Rik van Spronsen1Andy I. M. Hoepelman2Chantal P. Bleeker-Rovers3Jan Jelrik Oosterheert4Peter C. Wever5Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Internal Medicine and Infectious Diseases, Radboud Expertise Center for Q Fever, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, 3584 CX Utrecht, The NetherlandsDepartment of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, 5223 GZ ‘s-Hertogenbosch, The NetherlandsBackground: the geographical similarities of the Dutch 2007–2010 Q fever outbreak and the start of the 2020 coronavirus disease 19 (COVID-19) outbreak in the Netherlands raised questions and provided a unique opportunity to study an association between <i>Coxiella burnetii</i> infection and the outcome following SARS-CoV-2 infection. Methods: We performed a retrospective cohort study in two Dutch hospitals. We assessed evidence of previous <i>C. burnetii</i> infection in COVID-19 patients diagnosed at the ED during the first COVID-19 wave and compared a combined outcome of in-hospital mortality and intensive care unit (ICU) admission using adjusted odds ratios (OR). Results: In total, 629 patients were included with a mean age of 68.0 years. Evidence of previous <i>C. burnetii</i> infection was found in 117 patients (18.6%). The combined primary outcome occurred in 40.2% and 40.4% of patients with and without evidence of previous <i>C. burnetii</i> infection respectively (adjusted OR of 0.926 (95% CI 0.605–1.416)). The adjusted OR of the secondary outcomes in-hospital mortality, ICU-admission and regular ward admission did not show an association either. Conclusion: no influence of previous <i>C. burnetii</i> infection on the risk of ICU admission and/or mortality for patients with COVID-19 presenting at the ED was observed.https://www.mdpi.com/2077-0383/11/3/526<i>Coxiella burnetii</i>Q feverSARS-CoV-2COVID-19Dutch Q fever outbreak |
| spellingShingle | Jesper M. Weehuizen Rik van Spronsen Andy I. M. Hoepelman Chantal P. Bleeker-Rovers Jan Jelrik Oosterheert Peter C. Wever No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2 Journal of Clinical Medicine <i>Coxiella burnetii</i> Q fever SARS-CoV-2 COVID-19 Dutch Q fever outbreak |
| title | No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2 |
| title_full | No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2 |
| title_fullStr | No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2 |
| title_full_unstemmed | No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2 |
| title_short | No Influence of Previous <i>Coxiella burnetii</i> Infection on ICU Admission and Mortality in Emergency Department Patients Infected with SARS-CoV-2 |
| title_sort | no influence of previous i coxiella burnetii i infection on icu admission and mortality in emergency department patients infected with sars cov 2 |
| topic | <i>Coxiella burnetii</i> Q fever SARS-CoV-2 COVID-19 Dutch Q fever outbreak |
| url | https://www.mdpi.com/2077-0383/11/3/526 |
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