Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension
Aim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH).Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2020-09-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2422 |
| _version_ | 1797882420696973312 |
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| author | B. I. Geltser V. V. Orlova-Ilinskaya O. O. Vetrova V. N. Kotelnikov R. S. Karpov |
| author_facet | B. I. Geltser V. V. Orlova-Ilinskaya O. O. Vetrova V. N. Kotelnikov R. S. Karpov |
| author_sort | B. I. Geltser |
| collection | DOAJ |
| description | Aim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH).Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood pressure (BP), and there was no history of its increase. We conducted 24-hour ambulatory blood pressure monitoring (ABPM), carotid duplex scan with determination of the intima- media thickness (IMT). The levels of total cholesterol (TC), low (LDLC) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) were determined. Body mass index, visceral adiposity index, lipid accumulation product index and waist-to-height ratio were calculated. We performed clustering of ABPM data, calculated the odds ratio of association between cardiometabolic risk factors and certain MH phenotypes.Results. MH was diagnosed in 142 (68,6%) patients examined, divided into 3 clusters: systolic-diastolic — SDMH (50,7%), isolated systolic — ISMH (27,5%) and isolated diastolic — IDMH (21,8%). Impaired lipid metabolism, visceral adiposity, IMT increase and atherosclerotic plaques were more often recorded in patients with SDMH and IDMH. The levels of TC, LDL-C and IMT were highest in individuals with IDMH. Odds ratio analysis indicated significant associations of SDMH and IDMH phenotypes with indicators of visceral adiposity, IMT, TG, TC, LDL-C and TG/HDL-Cl.Conclusion. Clustering of ABPM data in individuals with MH and comparing related phenotypes with cardiometabolic risk factors complements their clinical and functional characteristics and can be a useful tool for improving customized prevention and therapy programs. |
| first_indexed | 2024-04-10T03:34:28Z |
| format | Article |
| id | doaj.art-c48dce232cb1475d8e4b20d1c3d25bbb |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:34:28Z |
| publishDate | 2020-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-c48dce232cb1475d8e4b20d1c3d25bbb2023-03-13T07:23:29Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252020-09-0119410.15829/1728-8800-2020-24222129Assessment of cardiometabolic risk factors in various phenotypes of masked hypertensionB. I. Geltser0V. V. Orlova-Ilinskaya1O. O. Vetrova2V. N. Kotelnikov3R. S. Karpov4ФГАОУ ВО Дальневосточный федеральный университет Минобрнауки РоссииФГАОУ ВО Дальневосточный федеральный университет Минобрнауки РоссииФГАОУ ВО Дальневосточный федеральный университет Минобрнауки РоссииФГАОУ ВО Дальневосточный федеральный университет Минобрнауки РоссииФГБНУ Томский национальный исследовательский медицинский центр Российской академии наук, Научно-исследовательский институт кардиологииAim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH).Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood pressure (BP), and there was no history of its increase. We conducted 24-hour ambulatory blood pressure monitoring (ABPM), carotid duplex scan with determination of the intima- media thickness (IMT). The levels of total cholesterol (TC), low (LDLC) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) were determined. Body mass index, visceral adiposity index, lipid accumulation product index and waist-to-height ratio were calculated. We performed clustering of ABPM data, calculated the odds ratio of association between cardiometabolic risk factors and certain MH phenotypes.Results. MH was diagnosed in 142 (68,6%) patients examined, divided into 3 clusters: systolic-diastolic — SDMH (50,7%), isolated systolic — ISMH (27,5%) and isolated diastolic — IDMH (21,8%). Impaired lipid metabolism, visceral adiposity, IMT increase and atherosclerotic plaques were more often recorded in patients with SDMH and IDMH. The levels of TC, LDL-C and IMT were highest in individuals with IDMH. Odds ratio analysis indicated significant associations of SDMH and IDMH phenotypes with indicators of visceral adiposity, IMT, TG, TC, LDL-C and TG/HDL-Cl.Conclusion. Clustering of ABPM data in individuals with MH and comparing related phenotypes with cardiometabolic risk factors complements their clinical and functional characteristics and can be a useful tool for improving customized prevention and therapy programs.https://cardiovascular.elpub.ru/jour/article/view/2422маскированная артериальная гипертензияфакторы рискакластерный анализ |
| spellingShingle | B. I. Geltser V. V. Orlova-Ilinskaya O. O. Vetrova V. N. Kotelnikov R. S. Karpov Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension Кардиоваскулярная терапия и профилактика маскированная артериальная гипертензия факторы риска кластерный анализ |
| title | Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
| title_full | Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
| title_fullStr | Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
| title_full_unstemmed | Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
| title_short | Assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
| title_sort | assessment of cardiometabolic risk factors in various phenotypes of masked hypertension |
| topic | маскированная артериальная гипертензия факторы риска кластерный анализ |
| url | https://cardiovascular.elpub.ru/jour/article/view/2422 |
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