Mesenchymal–epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression

Mesenchymal–epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression

Abstract Background Oral squamous cell carcinoma (OSCC), an HPV-negative head and neck cancer, frequently metastasizes to the regional lymph nodes but only occasionally beyond. Initial phases of metastasis are associated with an epithelial–mesenchymal transition (EMT), while the consolidation phase...

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Bibliographic Details
Main Authors: Kai Horny, Christoph Sproll, Lukas Peiffer, Frauke Furtmann, Patricia Gerhardt, Jan Gravemeyer, Nikolas H. Stoecklein, Ivelina Spassova, Jürgen C. Becker
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Translational Medicine
Subjects:
Single cell RNA
Oral cavity
Squamous cell carcinoma
Epithelial–mesenchymal plasticity
EMT
MET
Online Access:https://doi.org/10.1186/s12967-023-04102-w

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