Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis

Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis

Abstract Background Spondyloarthritis (SpA) is chronic inflammatory arthritis, and interleukin (IL)-17 is crucial in SpA pathogenesis. Type 17 helper T (Th17) cells are one of major IL-17-secreting cells. Signal transducer and activator of transcription (STAT)-3 signaling induces Th17 differentiatio...

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Bibliographic Details
Main Authors: Hong-Ki Min, JeongWon Choi, Seon-Yeong Lee, Hyeon-Beom Seo, KyungAh Jung, Hyun Sik Na, Jun-Geol Ryu, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Translational Medicine
Subjects:
Spondyloarthritis
PIAS3
Type 17 helper T cell
Regulatory T cell
Online Access:http://link.springer.com/article/10.1186/s12967-019-1774-x

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