Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis
BackgroundGlucose abnormalities and cognitive alterations are present before the onset of schizophrenia. We aimed to study whether glucose metabolism parameters are associated with cognitive functioning in recent-onset psychosis (ROP) patients while adjusting for hypothalamic-pituitary adrenal (HPA)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00455/full |
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| author | Itziar Montalvo Alexandre González-Rodríguez Ángel Cabezas Alfonso Gutiérrez-Zotes Montse Solé Maria José Algora Laura Ortega Lourdes Martorell Vanessa Sánchez-Gistau Elisabet Vilella Javier Labad |
| author_facet | Itziar Montalvo Alexandre González-Rodríguez Ángel Cabezas Alfonso Gutiérrez-Zotes Montse Solé Maria José Algora Laura Ortega Lourdes Martorell Vanessa Sánchez-Gistau Elisabet Vilella Javier Labad |
| author_sort | Itziar Montalvo |
| collection | DOAJ |
| description | BackgroundGlucose abnormalities and cognitive alterations are present before the onset of schizophrenia. We aimed to study whether glucose metabolism parameters are associated with cognitive functioning in recent-onset psychosis (ROP) patients while adjusting for hypothalamic-pituitary adrenal (HPA) axis measures.MethodsSixty ROP outpatients and 50 healthy subjects (HS) were studied. Cognitive function was assessed with the MATRICS Consensus Cognitive Battery. Glycated haemoglobin (HbA1c), glucose, insulin, and C-peptide levels were determined in plasma. The HOMA-insulin resistance index was calculated. Salivary samples were obtained at home on another day to assess the cortisol awakening response and cortisol levels during the day. Univariate analyses were conducted to explore the association between glucose metabolism parameters and cognitive tasks. For those parameters that were more clearly associated with the cognitive outcome, multiple linear regression analyses were conducted to adjust for covariates. Each cognitive task was considered the dependent variable. Covariates were age, sex, education level, diagnosis, antipsychotic and benzodiazepine treatment, body mass index (BMI), smoking, and HPA axis measures. Potential interactions between diagnosis and glucose parameters were tested.ResultsThere were no significant differences in HPA axis measures or glucose parameters, with the exception of C-peptide (that was higher in ROP patients), between groups. ROP patients had a lower performance than HS in all cognitive tasks (p < 0.01 for all tasks). Of all glucose metabolism parameters, HbA1c levels were more clearly associated with cognitive impairment in cognitive tasks dealing with executive functions and visual memory in both ROP patients and HS. Multivariate analyses found a significant negative association between HbA1c and cognitive functioning in five cognitive tasks dealing with executive functions, visual memory and attention/vigilance (a ROP diagnosis by HbA1c negative interaction was found in this latter cognitive domain, suggesting that HBA1c levels are associated with impaired attention only in ROP patients).ConclusionsOur study found that HbA1c was negatively associated with cognitive functioning in both ROP patients and HS in tasks dealing with executive functions and visual memory. In ROP patients, HbA1c was also associated with impaired attention. These results were independent of BMI and measures of HPA axis activity. |
| first_indexed | 2024-12-11T03:24:22Z |
| format | Article |
| id | doaj.art-c490ffcea44e476a82a13d296d341d40 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T03:24:22Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-c490ffcea44e476a82a13d296d341d402022-12-22T01:22:34ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-05-011110.3389/fpsyt.2020.00455537926Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset PsychosisItziar Montalvo0Alexandre González-Rodríguez1Ángel Cabezas2Alfonso Gutiérrez-Zotes3Montse Solé4Maria José Algora5Laura Ortega6Lourdes Martorell7Vanessa Sánchez-Gistau8Elisabet Vilella9Javier Labad10Department of Mental Health, Parc Taulí Hospital Universitari, Institut d’Investigació Sanitària Parc Taulí (I3PT), Universitat Autònoma de Barcelona, CIBERSAM, Sabadell, SpainDepartment of Mental Health, Parc Taulí Hospital Universitari, Institut d’Investigació Sanitària Parc Taulí (I3PT), Universitat Autònoma de Barcelona, CIBERSAM, Sabadell, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainNursing Department, Universitat Rovira i Vigili, Tarragona, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainHospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, CIBERSAM, Reus, SpainDepartment of Mental Health, Parc Taulí Hospital Universitari, Institut d’Investigació Sanitària Parc Taulí (I3PT), Universitat Autònoma de Barcelona, CIBERSAM, Sabadell, SpainBackgroundGlucose abnormalities and cognitive alterations are present before the onset of schizophrenia. We aimed to study whether glucose metabolism parameters are associated with cognitive functioning in recent-onset psychosis (ROP) patients while adjusting for hypothalamic-pituitary adrenal (HPA) axis measures.MethodsSixty ROP outpatients and 50 healthy subjects (HS) were studied. Cognitive function was assessed with the MATRICS Consensus Cognitive Battery. Glycated haemoglobin (HbA1c), glucose, insulin, and C-peptide levels were determined in plasma. The HOMA-insulin resistance index was calculated. Salivary samples were obtained at home on another day to assess the cortisol awakening response and cortisol levels during the day. Univariate analyses were conducted to explore the association between glucose metabolism parameters and cognitive tasks. For those parameters that were more clearly associated with the cognitive outcome, multiple linear regression analyses were conducted to adjust for covariates. Each cognitive task was considered the dependent variable. Covariates were age, sex, education level, diagnosis, antipsychotic and benzodiazepine treatment, body mass index (BMI), smoking, and HPA axis measures. Potential interactions between diagnosis and glucose parameters were tested.ResultsThere were no significant differences in HPA axis measures or glucose parameters, with the exception of C-peptide (that was higher in ROP patients), between groups. ROP patients had a lower performance than HS in all cognitive tasks (p < 0.01 for all tasks). Of all glucose metabolism parameters, HbA1c levels were more clearly associated with cognitive impairment in cognitive tasks dealing with executive functions and visual memory in both ROP patients and HS. Multivariate analyses found a significant negative association between HbA1c and cognitive functioning in five cognitive tasks dealing with executive functions, visual memory and attention/vigilance (a ROP diagnosis by HbA1c negative interaction was found in this latter cognitive domain, suggesting that HBA1c levels are associated with impaired attention only in ROP patients).ConclusionsOur study found that HbA1c was negatively associated with cognitive functioning in both ROP patients and HS in tasks dealing with executive functions and visual memory. In ROP patients, HbA1c was also associated with impaired attention. These results were independent of BMI and measures of HPA axis activity.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00455/fullglucoseglycated haemoglobincognitionearly psychosiscortisol |
| spellingShingle | Itziar Montalvo Alexandre González-Rodríguez Ángel Cabezas Alfonso Gutiérrez-Zotes Montse Solé Maria José Algora Laura Ortega Lourdes Martorell Vanessa Sánchez-Gistau Elisabet Vilella Javier Labad Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis Frontiers in Psychiatry glucose glycated haemoglobin cognition early psychosis cortisol |
| title | Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis |
| title_full | Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis |
| title_fullStr | Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis |
| title_full_unstemmed | Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis |
| title_short | Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis |
| title_sort | glycated haemoglobin is associated with poorer cognitive performance in patients with recent onset psychosis |
| topic | glucose glycated haemoglobin cognition early psychosis cortisol |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00455/full |
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