Potential Anti-Atherosclerotic Properties of Astaxanthin
Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of ath...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-02-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/14/2/35 |
| _version_ | 1811186005755035648 |
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| author | Yoshimi Kishimoto Hiroshi Yoshida Kazuo Kondo |
| author_facet | Yoshimi Kishimoto Hiroshi Yoshida Kazuo Kondo |
| author_sort | Yoshimi Kishimoto |
| collection | DOAJ |
| description | Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of atherosclerosis. Astaxanthin has a unique molecular structure that is responsible for its powerful antioxidant activities by quenching singlet oxygen and scavenging free radicals. Astaxanthin has been reported to inhibit low-density lipoprotein (LDL) oxidation and to increase high-density lipoprotein (HDL)-cholesterol and adiponectin levels in clinical studies. Accumulating evidence suggests that astaxanthin could exert preventive actions against atherosclerotic cardiovascular disease (CVD) via its potential to improve oxidative stress, inflammation, lipid metabolism, and glucose metabolism. In addition to identifying mechanisms of astaxanthin bioactivity by basic research, much more epidemiological and clinical evidence linking reduced CVD risk with dietary astaxanthin intake is needed. |
| first_indexed | 2024-04-11T13:40:08Z |
| format | Article |
| id | doaj.art-c4916336727743689b7c25a230bee642 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:40:08Z |
| publishDate | 2016-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-c4916336727743689b7c25a230bee6422022-12-22T04:21:19ZengMDPI AGMarine Drugs1660-33972016-02-011423510.3390/md14020035md14020035Potential Anti-Atherosclerotic Properties of AstaxanthinYoshimi Kishimoto0Hiroshi Yoshida1Kazuo Kondo2Endowed Research Department “Food for Health”, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, JapanDepartment of Laboratory Medicine, Jikei University Kashiwa Hospital, 163-1 Kashiwashita, Kashiwa, Chiba 277-8567, JapanEndowed Research Department “Food for Health”, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, JapanAstaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of atherosclerosis. Astaxanthin has a unique molecular structure that is responsible for its powerful antioxidant activities by quenching singlet oxygen and scavenging free radicals. Astaxanthin has been reported to inhibit low-density lipoprotein (LDL) oxidation and to increase high-density lipoprotein (HDL)-cholesterol and adiponectin levels in clinical studies. Accumulating evidence suggests that astaxanthin could exert preventive actions against atherosclerotic cardiovascular disease (CVD) via its potential to improve oxidative stress, inflammation, lipid metabolism, and glucose metabolism. In addition to identifying mechanisms of astaxanthin bioactivity by basic research, much more epidemiological and clinical evidence linking reduced CVD risk with dietary astaxanthin intake is needed.http://www.mdpi.com/1660-3397/14/2/35astaxanthinoxidative stressinflammationlipid metabolismglucose metabolismatherosclerosiscardiovascular disease |
| spellingShingle | Yoshimi Kishimoto Hiroshi Yoshida Kazuo Kondo Potential Anti-Atherosclerotic Properties of Astaxanthin Marine Drugs astaxanthin oxidative stress inflammation lipid metabolism glucose metabolism atherosclerosis cardiovascular disease |
| title | Potential Anti-Atherosclerotic Properties of Astaxanthin |
| title_full | Potential Anti-Atherosclerotic Properties of Astaxanthin |
| title_fullStr | Potential Anti-Atherosclerotic Properties of Astaxanthin |
| title_full_unstemmed | Potential Anti-Atherosclerotic Properties of Astaxanthin |
| title_short | Potential Anti-Atherosclerotic Properties of Astaxanthin |
| title_sort | potential anti atherosclerotic properties of astaxanthin |
| topic | astaxanthin oxidative stress inflammation lipid metabolism glucose metabolism atherosclerosis cardiovascular disease |
| url | http://www.mdpi.com/1660-3397/14/2/35 |
| work_keys_str_mv | AT yoshimikishimoto potentialantiatheroscleroticpropertiesofastaxanthin AT hiroshiyoshida potentialantiatheroscleroticpropertiesofastaxanthin AT kazuokondo potentialantiatheroscleroticpropertiesofastaxanthin |