Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback
Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32392-z |
| _version_ | 1811340101930713088 |
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| author | Joaquín Gutiérrez Mena Sant Kumar Mustafa Khammash |
| author_facet | Joaquín Gutiérrez Mena Sant Kumar Mustafa Khammash |
| author_sort | Joaquín Gutiérrez Mena |
| collection | DOAJ |
| description | Communities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop. |
| first_indexed | 2024-04-13T18:37:25Z |
| format | Article |
| id | doaj.art-c491d0537f1c4d25bed1d2e006a4e3ea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T18:37:25Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c491d0537f1c4d25bed1d2e006a4e3ea2022-12-22T02:34:51ZengNature PortfolioNature Communications2041-17232022-08-0113111610.1038/s41467-022-32392-zDynamic cybergenetic control of bacterial co-culture composition via optogenetic feedbackJoaquín Gutiérrez Mena0Sant Kumar1Mustafa Khammash2Department of Biosystems Science and Engineering (D-BSSE), ETH ZürichDepartment of Biosystems Science and Engineering (D-BSSE), ETH ZürichDepartment of Biosystems Science and Engineering (D-BSSE), ETH ZürichCommunities of microbes play important roles in natural environments and hold great potential for deploying division-of-labor strategies in synthetic biology and bioproduction. Here, in a community of two competing E. coli strains, the authors show that the relative abundances of the strains can be stabilized and steered dynamically with remarkable precision by coupling the cells to an automated computer-controlled feedback-loop.https://doi.org/10.1038/s41467-022-32392-z |
| spellingShingle | Joaquín Gutiérrez Mena Sant Kumar Mustafa Khammash Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback Nature Communications |
| title | Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback |
| title_full | Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback |
| title_fullStr | Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback |
| title_full_unstemmed | Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback |
| title_short | Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback |
| title_sort | dynamic cybergenetic control of bacterial co culture composition via optogenetic feedback |
| url | https://doi.org/10.1038/s41467-022-32392-z |
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