COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS
Objective: To evaluate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with procalcitonin in cord blood. Study Design: Case control study. Place and Duration of Study: Study was conducted in Army Medical College and Pak Emirates Military Hosp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2020-06-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/4670/2739 |
| _version_ | 1819008154199916544 |
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| author | Sadia Israr Asma Hayat Tariq Mahmood Ahmad Numan Majeed Sakeena Hussain Naqvi Saema Tehseen |
| author_facet | Sadia Israr Asma Hayat Tariq Mahmood Ahmad Numan Majeed Sakeena Hussain Naqvi Saema Tehseen |
| author_sort | Sadia Israr |
| collection | DOAJ |
| description | Objective: To evaluate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with procalcitonin in cord blood.
Study Design: Case control study.
Place and Duration of Study: Study was conducted in Army Medical College and Pak Emirates Military Hospital Rawalpindi, Jul 2018 to Mar 2019.
Methodology: Those mothers, having deliveries with early rupture of membranes (EROM), premature rupture of membranes (PROM), preterm, dai handled, meconium and failure of induction have been included. Total 60 neonates were included in this study. Nineteen neonates were taken as a continuous clinical unsteadiness with a clearly documented suspicion of sepsis and two neonatologists decided sepsis within 1-3 days of life. While remaining neonates were control who have no infection.
Results: Laboratory values show there was a gross difference in mean values of case and control for white blood cell (WBC), platelets, neutrophil, platelet to lymphocyte ratio and procalcitonin with statistical significance except lymphocyte count and neutrophil to lymphocyte ratio. In combined ROC curve. The cutoff of procalcitonin was calculated to be 0.4ng/ml with an area under curve of 84.5%. Similarly, cutoff of neutrophil to lymphocyte ratio was determined to be 1.39 with an area under curve of 65.1% at sensitivity of 63% and specificity of 58.5%. Cutoff of platelet to lymphocyte ratio was determined to be 47.48 with an area under curve of 66.8% at sensitivity of 78.9% and specificity of 49%.
Conclusion: Combined hematological markers neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with procalcitonin in cord blood could be used as a simple, sensitive and predictive parameter for identifying neonates susceptible to sepsis. |
| first_indexed | 2024-12-21T00:35:57Z |
| format | Article |
| id | doaj.art-c491eb50a6704b71aed8470856e71de4 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-21T00:35:57Z |
| publishDate | 2020-06-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-c491eb50a6704b71aed8470856e71de42022-12-21T19:21:48ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422020-06-01703824829COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSISSadia Israr0Asma Hayat1Tariq Mahmood Ahmad2Numan Majeed3Sakeena Hussain Naqvi4Saema Tehseen5Army Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmy Medical College/National University of Medical Sciences (NUMS) Rawalpindi PakistanPakistan Aeronautical Complex, Kamra PakistanPakistan Aeronautical Complex, Kamra PakistanObjective: To evaluate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with procalcitonin in cord blood. Study Design: Case control study. Place and Duration of Study: Study was conducted in Army Medical College and Pak Emirates Military Hospital Rawalpindi, Jul 2018 to Mar 2019. Methodology: Those mothers, having deliveries with early rupture of membranes (EROM), premature rupture of membranes (PROM), preterm, dai handled, meconium and failure of induction have been included. Total 60 neonates were included in this study. Nineteen neonates were taken as a continuous clinical unsteadiness with a clearly documented suspicion of sepsis and two neonatologists decided sepsis within 1-3 days of life. While remaining neonates were control who have no infection. Results: Laboratory values show there was a gross difference in mean values of case and control for white blood cell (WBC), platelets, neutrophil, platelet to lymphocyte ratio and procalcitonin with statistical significance except lymphocyte count and neutrophil to lymphocyte ratio. In combined ROC curve. The cutoff of procalcitonin was calculated to be 0.4ng/ml with an area under curve of 84.5%. Similarly, cutoff of neutrophil to lymphocyte ratio was determined to be 1.39 with an area under curve of 65.1% at sensitivity of 63% and specificity of 58.5%. Cutoff of platelet to lymphocyte ratio was determined to be 47.48 with an area under curve of 66.8% at sensitivity of 78.9% and specificity of 49%. Conclusion: Combined hematological markers neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with procalcitonin in cord blood could be used as a simple, sensitive and predictive parameter for identifying neonates susceptible to sepsis.https://www.pafmj.org/index.php/PAFMJ/article/view/4670/2739early rupture of membrane (erom)neutrophil to lymphocyte ratio (nlr)platelet to lymphocyte ratio (plr) |
| spellingShingle | Sadia Israr Asma Hayat Tariq Mahmood Ahmad Numan Majeed Sakeena Hussain Naqvi Saema Tehseen COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS Pakistan Armed Forces Medical Journal early rupture of membrane (erom) neutrophil to lymphocyte ratio (nlr) platelet to lymphocyte ratio (plr) |
| title | COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS |
| title_full | COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS |
| title_fullStr | COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS |
| title_full_unstemmed | COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS |
| title_short | COMPARISON OF PROCALCITONIN AND HEMATTOLOGICAL RATIOS IN CORD BLOOD AS EARLY PREDICTIVE MARKER OF NEONATAL SEPSIS |
| title_sort | comparison of procalcitonin and hemattological ratios in cord blood as early predictive marker of neonatal sepsis |
| topic | early rupture of membrane (erom) neutrophil to lymphocyte ratio (nlr) platelet to lymphocyte ratio (plr) |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/4670/2739 |
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