Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review
Advances in medicine have improved outcomes in children diagnosed with cancer, with overall 5-year survival rates for these children now exceeding 80%. Two-thirds of childhood cancer survivors have at least one late effect of cancer therapy, with one-third having serious or even life-threatening eff...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/20/5064 |
| _version_ | 1797515175887110144 |
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| author | Jarmila Kruseova Ales Vicha Barbara Feriancikova Tomas Eckschlager |
| author_facet | Jarmila Kruseova Ales Vicha Barbara Feriancikova Tomas Eckschlager |
| author_sort | Jarmila Kruseova |
| collection | DOAJ |
| description | Advances in medicine have improved outcomes in children diagnosed with cancer, with overall 5-year survival rates for these children now exceeding 80%. Two-thirds of childhood cancer survivors have at least one late effect of cancer therapy, with one-third having serious or even life-threatening effects. One of the most serious late effects is a development of subsequent malignant neoplasms (histologically different cancers, which appear after the treatment for primary cancer), which occur in about 3–10% of survivors and are associated with high mortality. In cancers with a very good prognosis, subsequent malignant neoplasms significantly affect long-term survival. Therefore, there is an effort to reduce particularly hazardous treatments. This review discusses the importance of individual factors (gender, genetic factors, cytostatic drugs, radiotherapy) in the development of subsequent malignant neoplasms and the possibilities of their prediction and prevention in the future. |
| first_indexed | 2024-03-10T06:41:49Z |
| format | Article |
| id | doaj.art-c4930d00804149228895fb121f5d35e0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T06:41:49Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c4930d00804149228895fb121f5d35e02023-11-22T17:39:43ZengMDPI AGCancers2072-66942021-10-011320506410.3390/cancers13205064Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A ReviewJarmila Kruseova0Ales Vicha1Barbara Feriancikova2Tomas Eckschlager3Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84/1, 150 06 Prague 5, Czech RepublicDepartment of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84/1, 150 06 Prague 5, Czech RepublicDepartment of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84/1, 150 06 Prague 5, Czech RepublicDepartment of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84/1, 150 06 Prague 5, Czech RepublicAdvances in medicine have improved outcomes in children diagnosed with cancer, with overall 5-year survival rates for these children now exceeding 80%. Two-thirds of childhood cancer survivors have at least one late effect of cancer therapy, with one-third having serious or even life-threatening effects. One of the most serious late effects is a development of subsequent malignant neoplasms (histologically different cancers, which appear after the treatment for primary cancer), which occur in about 3–10% of survivors and are associated with high mortality. In cancers with a very good prognosis, subsequent malignant neoplasms significantly affect long-term survival. Therefore, there is an effort to reduce particularly hazardous treatments. This review discusses the importance of individual factors (gender, genetic factors, cytostatic drugs, radiotherapy) in the development of subsequent malignant neoplasms and the possibilities of their prediction and prevention in the future.https://www.mdpi.com/2072-6694/13/20/5064subsequent malignant neoplasmschildhood cancer survivorsgenetic factorscancer predisposition syndromeschemotherapyradiotherapy |
| spellingShingle | Jarmila Kruseova Ales Vicha Barbara Feriancikova Tomas Eckschlager Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review Cancers subsequent malignant neoplasms childhood cancer survivors genetic factors cancer predisposition syndromes chemotherapy radiotherapy |
| title | Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review |
| title_full | Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review |
| title_fullStr | Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review |
| title_full_unstemmed | Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review |
| title_short | Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review |
| title_sort | possible mechanisms of subsequent neoplasia development in childhood cancer survivors a review |
| topic | subsequent malignant neoplasms childhood cancer survivors genetic factors cancer predisposition syndromes chemotherapy radiotherapy |
| url | https://www.mdpi.com/2072-6694/13/20/5064 |
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