Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults
Luxiang Shang,1 Rui Li,2 Yang Zhao,3 Huaxin Sun,3 Baopeng Tang,3 Yinglong Hou1 1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-08-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-chinese-visceral-adiposity-index-and-incident-type-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1811173628843130880 |
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| author | Shang L Li R Zhao Y Sun H Tang B Hou Y |
| author_facet | Shang L Li R Zhao Y Sun H Tang B Hou Y |
| author_sort | Shang L |
| collection | DOAJ |
| description | Luxiang Shang,1 Rui Li,2 Yang Zhao,3 Huaxin Sun,3 Baopeng Tang,3 Yinglong Hou1 1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, Shandong, People’s Republic of China; 2Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, People’s Republic of China; 3Department of Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Yinglong HouDepartment of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, No. 16766, Jingshi Road, Jinan, Shandong, 250014, People’s Republic of ChinaTel +86 531-89269317Email yinglonghou@hotmail.comBackground: Obesity is a well-known risk factor for type 2 diabetes mellitus (T2DM). Studies have shown that the Chinese visceral adiposity index (CVAI), a novel visceral adiposity indicator, is positive associated with the risk of T2DM in the Chinese population. This study aimed to investigate the correlation between CVAI and incident T2DM in a Japanese population.Methods: We performed a secondary analysis of open-access data from a retrospective cohort study. This study included 15,464 participants who received regular medical examinations at Murakami Memorial Hospital. All participants underwent a questionnaire survey, physical examination, and blood biochemical testing at baseline. The main outcome was new-onset T2DM during follow-up. Cox regression analysis and Kaplan–Meier analysis were used to analyze the risk of CVAI on T2DM, and we conducted smooth curve fitting. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of CVAI, body mass index (BMI), and waist circumference (WC) for incident T2DM.Results: During a median follow-up time of 5.39 years, 373 new-onset T2DM events were observed. Kaplan–Meier curves showed that the incidence of T2DM increased as the CVAI increased (log-rank χ2 = 187.1076 and 129.6067 in males and females, respectively, both P < 0.001). After adjustment for covariates, per 1 increase of CVAI was associated with a 1.0133-fold and 1.0246-fold higher risk of incident T2DM in males and females, respectively (both P < 0.001). Those individuals in the top CVAI quartile group had the highest risk of new-onset T2DM (HR = 3.1568 and 5.8415 in males and females, respectively, both P < 0.05). A nonlinear relationship was identified by the smooth fitting curve between CVAI and T2DM events in both genders. ROC analysis indicated that CVAI had better predictive power than BMI and WC in both genders.Conclusion: Our results demonstrate that CVAI was significantly associated with an increased risk of new-onset T2DM in Japanese adults.Keywords: diabetes mellitus, type 2 diabetes mellitus, Chinese visceral adiposity index, obesity, cohort study, Japanese adults |
| first_indexed | 2024-04-10T17:50:07Z |
| format | Article |
| id | doaj.art-c49531157a8d4bcaab982698dd808c7c |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:50:07Z |
| publishDate | 2021-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-c49531157a8d4bcaab982698dd808c7c2023-02-02T22:04:22ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072021-08-01Volume 143743375168182Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese AdultsShang LLi RZhao YSun HTang BHou YLuxiang Shang,1 Rui Li,2 Yang Zhao,3 Huaxin Sun,3 Baopeng Tang,3 Yinglong Hou1 1Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, Shandong, People’s Republic of China; 2Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, People’s Republic of China; 3Department of Pacing and Electrophysiology, Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Yinglong HouDepartment of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, No. 16766, Jingshi Road, Jinan, Shandong, 250014, People’s Republic of ChinaTel +86 531-89269317Email yinglonghou@hotmail.comBackground: Obesity is a well-known risk factor for type 2 diabetes mellitus (T2DM). Studies have shown that the Chinese visceral adiposity index (CVAI), a novel visceral adiposity indicator, is positive associated with the risk of T2DM in the Chinese population. This study aimed to investigate the correlation between CVAI and incident T2DM in a Japanese population.Methods: We performed a secondary analysis of open-access data from a retrospective cohort study. This study included 15,464 participants who received regular medical examinations at Murakami Memorial Hospital. All participants underwent a questionnaire survey, physical examination, and blood biochemical testing at baseline. The main outcome was new-onset T2DM during follow-up. Cox regression analysis and Kaplan–Meier analysis were used to analyze the risk of CVAI on T2DM, and we conducted smooth curve fitting. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of CVAI, body mass index (BMI), and waist circumference (WC) for incident T2DM.Results: During a median follow-up time of 5.39 years, 373 new-onset T2DM events were observed. Kaplan–Meier curves showed that the incidence of T2DM increased as the CVAI increased (log-rank χ2 = 187.1076 and 129.6067 in males and females, respectively, both P < 0.001). After adjustment for covariates, per 1 increase of CVAI was associated with a 1.0133-fold and 1.0246-fold higher risk of incident T2DM in males and females, respectively (both P < 0.001). Those individuals in the top CVAI quartile group had the highest risk of new-onset T2DM (HR = 3.1568 and 5.8415 in males and females, respectively, both P < 0.05). A nonlinear relationship was identified by the smooth fitting curve between CVAI and T2DM events in both genders. ROC analysis indicated that CVAI had better predictive power than BMI and WC in both genders.Conclusion: Our results demonstrate that CVAI was significantly associated with an increased risk of new-onset T2DM in Japanese adults.Keywords: diabetes mellitus, type 2 diabetes mellitus, Chinese visceral adiposity index, obesity, cohort study, Japanese adultshttps://www.dovepress.com/association-between-chinese-visceral-adiposity-index-and-incident-type-peer-reviewed-fulltext-article-DMSOdiabetes mellitustype 2 diabetes mellituschinese visceral adiposity indexobesitycohort studyjapanese adults. |
| spellingShingle | Shang L Li R Zhao Y Sun H Tang B Hou Y Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults Diabetes, Metabolic Syndrome and Obesity diabetes mellitus type 2 diabetes mellitus chinese visceral adiposity index obesity cohort study japanese adults. |
| title | Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults |
| title_full | Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults |
| title_fullStr | Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults |
| title_full_unstemmed | Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults |
| title_short | Association Between Chinese Visceral Adiposity Index and Incident Type 2 Diabetes Mellitus in Japanese Adults |
| title_sort | association between chinese visceral adiposity index and incident type 2 diabetes mellitus in japanese adults |
| topic | diabetes mellitus type 2 diabetes mellitus chinese visceral adiposity index obesity cohort study japanese adults. |
| url | https://www.dovepress.com/association-between-chinese-visceral-adiposity-index-and-incident-type-peer-reviewed-fulltext-article-DMSO |
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